Isomerization Kinetics of Panipenem in Aqueous Solution

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概要

• 論文の詳細を見る

• The isomerization kinetics of panipenem (INN: (+)-(5R,6S)-3-[(S)-1-(acetimidoylpyrrolidin-3-yl)thio]-6-[(R)-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, CAS No.87726-17-8) in aqueous solution were investigated. An equilibrium between the Z-form and E-form was observed, and it was found that the isomerization rates were affected by the pH of the solution. Under acidic conditions, the isomerization rates were small. However, the isomerization rates were increased with the pH value. This phenomenon resulted from the extent of proton dissociation from the acetimidoyl group.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• Takayama Kozo

  Department of Pharmaceutics, Hoshi University

• Takayama Kozo

  Department Of Pharmaceutics Hoshi University

• Takayama Kozo

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University

• Takayama Kozo

  Dep. Of Pharmaceutics Hoshi Univ.

• Suzuki Masahiko

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• ITO Nobuya

  Pharmaceutical Development Laboratories, SANKYO CO., LTD.

• SUZUKI Masahiko

  Pharmaceutical Development Laboratories, SANKYO CO., LTD.

• KUSAI Akira

  Pharmaceutical Development Laboratories, SANKYO CO., LTD.

• Kusai A

  Jeol Ltd. Tokyo Jpn

• Kusai Akira

  Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd.

• Ito Nobuya

  Pharmaceutical Development Laboratories Sankyo Co. Ltd.

• Takayama Kozo

  Department of Drug Delivery Research, Hoshi University

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