Isomerization Kinetics of Panipenem in Aqueous Solution
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概要
- 論文の詳細を見る
The isomerization kinetics of panipenem (INN: (+)-(5R,6S)-3-[(S)-1-(acetimidoylpyrrolidin-3-yl)thio]-6-[(R)-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, CAS No.87726-17-8) in aqueous solution were investigated. An equilibrium between the Z-form and E-form was observed, and it was found that the isomerization rates were affected by the pH of the solution. Under acidic conditions, the isomerization rates were small. However, the isomerization rates were increased with the pH value. This phenomenon resulted from the extent of proton dissociation from the acetimidoyl group.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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Takayama Kozo
Dep. Of Pharmaceutics Hoshi Univ.
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Suzuki Masahiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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ITO Nobuya
Pharmaceutical Development Laboratories, SANKYO CO., LTD.
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SUZUKI Masahiko
Pharmaceutical Development Laboratories, SANKYO CO., LTD.
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KUSAI Akira
Pharmaceutical Development Laboratories, SANKYO CO., LTD.
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Kusai A
Jeol Ltd. Tokyo Jpn
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Kusai Akira
Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd.
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Ito Nobuya
Pharmaceutical Development Laboratories Sankyo Co. Ltd.
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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