Formulation of Liposomes with a Soybean-Derived Sterylglucoside Mixture and Cholesterol for Liver Targeting
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概要
- 論文の詳細を見る
In this study, we investigated a liposomal formulation of dipalmitoylphosphatidylcholine (DPPC) with a soybean-derived sterylglucoside mixture (SG) and cholesterol (Ch) for targeting the liver in mice. We found two distribution profiles of liposomes (reverse-phase evaporation vesicles, REV) in the liver depending on the concentration of Ch and SG in vivo; Ch tends to enhance liposomes containing 10 mol% SG accumulation in the liver, but to decrease those containing 20 mol% SG, and it prolongs the circulation in blood. Dicetylphosphate did not enhance liver targeting by liposomes with SG and Ch. More DPPC/SG/Ch-liposomes (6 : 1 : 3) were significantly taken up by cultivated hepatocytes than DPPC/SG/Ch-liposomes (6 : 0 : 4), suggesting a glucose residue. The optimal composition for the maximal liver targeting was a mixture of 0.2 μm DPPC/SG/Ch-liposomes (REV) at a molar ratio of 6 : 1 : 3. This composition of liposomes was distributed 3 times greater in hepatocytes than non-parenchymal cells 1 h after intravenous injection.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Shimizu Kazuyuki
Department Of Biochemical Engineering & Science Kyushu Institute Of Technology
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Shimizu K
Department Of Pharmaceutics Hoshi University
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Maitani Y
Institute Of Medicinal Chemistry Hoshi University
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Maitani Yoshie
Department Of Pharmaceutics Hoshi University
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Nagai T
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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NAGAI TSUNEJI
Department of Pharmaceutics, Hoshi University
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Takayama Kozo
Dep. Of Pharmaceutics Hoshi Univ.
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SHIMIZU Kazuyuki
Faculty of Pharmaceutical Sciences, Hoshi University
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Maitani Yoshie
Faculty Of Pharmaceutical Sciences Hoshi University
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Nagai Tsuneji
Department Of Pharmaceutics Hoshi University
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Shimizu Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
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Shimizu Kazuyuki
Department Of Biochem.engineering And Science Kyushu Institute Of Technology
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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Maitani Yoshie
Department of Drug Delivery Research, Hoshi University
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Shimizu Kazuyuki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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Nagai Tsuneji
Department of Drug Delivery Research, Hoshi University
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