Dipalmitoylphosphatidylcholine Liposomes with Soybean-Derived Sterols and Cholesterol as a Carrier for the Oral Administration of Insulin in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Dipalmitoylphosphatidylcholine (DPPC) liposomes with a soybean-derived sterol mixture (SS) or cholesterol (Ch) were examined as a carrier for the oral administration of insulin in rats. Four kinds of liposomes were prepared : liposomes containing SS or Ch (molar ratio of DPPC/X=7 : 2 or 7 : 4,X=SS or Ch), respectively. The pharmacological availability was greater and the lag time for the glucose reduction was later in the order of DPPC/SS (7 : 4)>DPPC/SS (7 : 2)>DPPC/Ch (7 : 4)≫DPPC/Ch (7 : 2)-liposomes. This order appears to correspond well with that of the rigidity of the liposomal membrane. In particular, DPPC/SS (7 : 4)-liposomes reduced blood glucose levels for up to 21 h in rats after oral administration. The highest absolute pharmacological availability was 31.6% at a dose of 20.0 IU/kg of DPPC/SS (7 : 4)-liposomes among the liposomes in comparison to intravenous administration.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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Maitani Y
Institute Of Medicinal Chemistry Hoshi University
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Maitani Yoshie
Department Of Pharmaceutics Hoshi University
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NAGAI TSUNEJI
Department of Pharmaceutics, Hoshi University
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MURAMATSU Kazunori
Department of Pharmaceutics, Hoshi University
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Maitani Yoshie
Faculty Of Pharmaceutical Sciences Hoshi University
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Nagai Tsuneji
Department Of Pharmaceutics Hoshi University
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Muramatsu Kazunori
Department Of Pharmaceutics Hoshi University
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Maitani Yoshie
Department of Drug Delivery Research, Hoshi University
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Nagai Tsuneji
Department of Drug Delivery Research, Hoshi University
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