Evaluation of Shikonin on Granulation Tissue Formation Compared with Carrageenan

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概要

• 論文の詳細を見る

• The effect of shikonin (SK) on granulation tissue formation was biochemically evaluated and the biological effect of SK on cotton pellet induced granulation tissue formation and the induction of hind paw edema was compared with that of λ-carrageenan (carrageenan) in rats. The dry weight of granulation tissue formed was increased by SK. The amounts of hemoglobin and hydroxyproline in granulation tissue were also increased by SK. These results suggest that SK has an enhancing effect on the formation of granulation tissue, accompanied by the proliferation of capillaries and the increased production of collagen in rats. SK showed mild stimulation toward swelling when injected into the hind paws of rats, as did carrageenan, while it showed a marked enhancing effect on granulation tissue formation compared with carrageenan. These results suggest that the mechanism underlying the biological effect of SK on granulation tissue formation is different from that of carrageenan, though the mild stimulation by SK might still contribute in part to the enhancing effect on granulation tissue formation.

• 公益社団法人日本薬学会の論文
• 1998-09-15

著者

• Maitani Yoshie

  Department Of Pharmaceutics Hoshi University

• NAGAI TSUNEJI

  Department of Pharmaceutics, Hoshi University

• Nagai Tsuneji

  Department Of Pharmaceutics Hoshi University

• SEKINE Takashi

  Pharmaceutical Technology Department of Central Research Laboratories, Tsumura & Co.

• KOJIMA Koji

  Pharmaceutical Technology Department of Central Research Laboratories, Tsumura & Co.

• MATSUMOTO Takaaki

  Pharmaceutical Technology Department of Central Research Laboratories, Tsumura & Co.

• YAMAMOTO Takeshi

  Pharmaceutical Technology Department of Central Research Laboratories, Tsumura & Co.

• Sekine Takashi

  Pharmaceutical Technology Department Of Central Research Laboratories Tsumura & Co.

• Matsumoto Takaaki

  Pharmaceutical Technology Department Of Central Research Laboratories Tsumura & Co.

• Yamamoto Takeshi

  Pharmaceutical Technology Department Of Central Research Laboratories Tsumura & Co.

• Maitani Yoshie

  Department of Health Chemistry, Hoshi University

• Maitani Yoshie

  Department of Drug Delivery Research, Hoshi University

• Nagai Tsuneji

  Department of Drug Delivery Research, Hoshi University

• Kojima Koji

  Pharmaceutical Technology Department of Central Research Laboratories, Tsumura & Co.

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