Relation of Rigidity of Membrane and Stability of Dipalmitoylphosphatidylcholine Liposomes with Soybean-Derived Sterols Prepared by Reverse Phase Evaporation Vesicle Method
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概要
- 論文の詳細を見る
A soybean-derived sterol mixture (SS) was used to stabilize liposomes prepared from dipalmitoylphosphatidylcholine (DPPC). The effect of SS on the stability and rigidity of liposomes entrapping calcein was investigated by measuring retentivity of calcein in liposomes in vitro and in vivo, and by fluorescence anisotropy, respectively. The entrapment efficiency is directly proportional to the total concentration of DPPC and SS. The presence of SS tends to increase the rigidity of the bilayer above its gel-liquid crystalline phase transition temperature of liposomes, and SS tends to fluidize the bilayer below its gel-liquid crystalline phase transition temperature. The relation between the stability of DPPC-liposomes with SS and the rigidity of liposomal membrane was discussed.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Maitani Y
Institute Of Medicinal Chemistry Hoshi University
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Maitani Yoshie
Department Of Pharmaceutics Hoshi University
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斉 憲栄
北京医科大学薬学院
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NAGAI TSUNEJI
Department of Pharmaceutics, Hoshi University
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QI Xian-Rong
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University
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Maitani Yoshie
Faculty Of Pharmaceutical Sciences Hoshi University
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Qi Xian-rong
School Of Pharmaceutical Science Beijing Medical University
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Qi Xian-rong
Department Of Pharmaceutics School Of Pharmaceutical Sciences Peking University
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Nagai Tsuneji
Department Of Pharmaceutics Hoshi University
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Maitani Yoshie
Department of Drug Delivery Research, Hoshi University
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Nagai Tsuneji
Department of Drug Delivery Research, Hoshi University
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