High Absorbency and Subchronic Morphologic Effects on the Nasal Epithelium of a Nasal Insulin Powder Dosage Form with a Soybean-derived Sterylglucoside Mixture in Rabbits
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概要
- 論文の詳細を見る
A soybean-derived steryglucoside mixture (SG) is a potential enhancer of the nasal absorption of insulin.The aim of the study was to examine the absorption of insulin given as the powder dosage form with SG and excipient and to determine the subchronic effects of SG on the morphology of rabbit nasal epithelium. The insulin powder dosage form with SG was administered to the rabbit nasal cavity for five successive days. The average bioavailability and the average pharmacological bioavailability of insulin were about 25.0 and 61.6% respectively. The nasal mucosa was taken from the nasal cavity and side-effects were investigated using an optiphoto light microscope. The insulin powder dosage form with SG produced no signs of inflammation, erosion or squamous metaplasia. These findings indicate that SG can be considered as a safe and effective enhancer and excipient in the nasal insulin powder dosage form.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Maitani Y
Institute Of Medicinal Chemistry Hoshi University
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Maitani Yoshie
Department Of Pharmaceutics Hoshi University
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Nagai T
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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NAGAI TSUNEJI
Department of Pharmaceutics, Hoshi University
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Ando T
Okayama Prefectural Univ. Okayama Jpn
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Takayama Kozo
Dep. Of Pharmaceutics Hoshi Univ.
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YAMAMOTO Tomonaga
Department of Pharmaceutics, Hoshi University
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ANDO Taeko
Department of Pharmaceutics, Hoshi University
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ISOWA Koichi
Center of Japan Biological Chemistry Co., Ltd.
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Maitani Yoshie
Faculty Of Pharmaceutical Sciences Hoshi University
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Ando Taeko
Department Of Communication Engineering Faculty Of Computer Science And System Engineering Okayama P
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Isowa K
Center Of Japan Biological Chemistry Co. Ltd.
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Nagai Tsuneji
Department Of Pharmaceutics Hoshi University
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Yamamoto T
Institute Of Life Science Research Asahi Chemical Co. Ltd.
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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Isowa Koichi
Center of Japan Biological Chemistry Co. Ltd.
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Maitani Yoshie
Department of Drug Delivery Research, Hoshi University
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Nagai Tsuneji
Department of Drug Delivery Research, Hoshi University
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