Isolation, Purification, and Characterization of Cyclomaltotetradecaose (ι-Cyclodextrin), Cyclomaltopentadecaose (κ-Cyclodextrin), Cyclomaltohexadecaose (λ-Cyclodextrin), and Cyclomaltoheptadecaose(μ-Cyclodextrin)

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概要

• 論文の詳細を見る

• Although it has already been found that cyclodextrin glucanotransferase (CGTase) produces cyclodextrins(CDs) composed of six to thirteen glycopyranose units, the existence of CDs which have more than fourteen glycopyranose units has still not been confirmed. Cyclomaltotetradecaose (ι-CD), cyclomaltopentadecaose (κ-CD), cyclomaltohexadecaose (λ-CD) and cyclomaltoheptadecaose (μ-CD) are a new series of large-ring CDs composed of 14-17 α-(1→4)-linked D-glycopyranose units, respectively. ι-, κ-, λ- and μ-CD were purified from the commercially available CD powder produced by CGTase, by a combination of HPLC and column chromatography. The molecular weights of ι-, κ-, λ- and μ-CD were determined by FAB-MS, and their cyclic structures were identified by ^1H-NMR and ^<13>C-NMR. The ^<13>C-NMR chemical shifts of ι-, κ-, λ- and μ-CD were elucidated and compared with those of δ-, ε-, ζ-, η- and θ-CD, and their structures were predicted from the results.

• 社団法人日本薬学会の論文
• 1997-11-15

著者

• Shigihara Atsushi

  Information Science Laboratory Hoshi University

• Nagase Hidetaka

  大鵬薬品工業

• Shigihara Atsushi

  Fac. Of Pharmaceutical Sciences Hoshi Univ. Shinagawa Tokyo 142-8501 Jpn

• Endo T

  Graduate School Of Pharmaceutical Sciences Hokkaido University

• Endo T

  Department Of Physical Chemistry Hoshi University

• Endo Tomohiro

  Department of Materials, Physics and Energy Engineering, Nagoya University

• Nagai T

  Department Of Pharmaceutics Hoshi University

• NAGASE Hiromasa

  Department of Physical Chemistry, Hoshi University

• UEDA Haruhisa

  Department of Physical Chemistry, Hoshi University

• NAGAI Tsuneji

  Faculty of Pharmaceutical Sciences, Hoshi University

• KOBAYASHI Shoichi

  Akita Research Institute of Food & Brewing

• Ueda H

  Kyoto Pharmaceutical University

• Kobayashi S

  Eisai Research Institute Of Boston Inc.

• Ueda H

  Hoshi Univ. Tokyo Jpn

• Ueda H

  Department Of Physical Chemistry Hoshi University

• Ueda H

  Faculty Of Pharmaceutical Sciences Hoshi University

• Ueda Haruhisa

  Faculty Of Pharmaceutical Science Hoshi University

• Ueda Haruhisa

  Department Of Physical Chemistry Hoshi University

• Kobayashi Shoichi

  Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni

• Ueda Hideo

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Kobayashi Shigeki

  Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University

• Ueda H

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Kobayashi Shigeki

  Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University

• Kobayashi Shigeki

  Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.

• Nagase H

  Pharmacobioregulation Research Laboratory Taiho Pharmaceutical Co. Ltd.

• Nagai Tsuneji

  Faculty Of Pharmaceutical Sciences Hoshi University

• Endo Tomohiro

  Department Of Material Physics And Energy Engineering Graduate School Of Engineering Nagoya Universi

• Endo Tomohiro

  Department Of Functional Radiation Sciences Hoshi University

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