Preparation and Drug Release Characteristics of the Conjugates of Mitomycin C with Glycol-chitosan and N-Succinyl-chitosan
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概要
- 論文の詳細を見る
Mitomycin C (MMC) was covalently attached to glycol-chitosan (Gly-chitosan) and N-succinyl-chitosan (N-Suc-chitosan) through a spacer of the glutaryl group, and each conjugate was obtained as a water-soluble product. Stability of 1a-(4-carboxybutyryl)-MMC (Glu-MMC) in vitro was investigated by incubation in 1/15M phosphate buffers of pH 5,6,7.4,8 and 9 at 37℃. The release rate of MMC from Glu-MMC was very slow at neutral pH, gradual at basic pH and relatively fast at acidic pH, but the quick decomposition of MMC proceeded simultaneously at acidic pH. Release of MMC from the conjugates in vitro was investigated by incubation in 1/15M phosphate buffers of pH 5,7.4 and 9 at 37℃. The release rate of MMC from the conjugates was slight at acidic pH, accelerated at basic pH, and was gradual at pH 7.4. In a plasma-buffer (pH 7.4) mixture (1 : 1,v/v), the release rate of MMC from the conjugates was rather similar to that in only the buffer (pH 7.4).
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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佐藤 正基
School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation
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Satoh M
Showa Pharmaceutical Univ. Tokyo Jpn
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Sato M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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NAGAI Tsuneji
Faculty of Pharmaceutical Sciences, Hoshi University
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SATO Mitsutaka
Faculty of Science and Technology, Hirosaki University
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MACHIDA YOSHIHARU
Faculty of Pharmaceutical Sciences, Hoshi University
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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ONISHI Hiraku
Faculty of Pharmaceutical Sciences, Hoshi University
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KITANO Manabu
Faculty of Pharmaceutical Sciences, Hoshi University
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Onishi Hiraku
Department Of Drug Delivery Research Hoshi University
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Onishi Hiraku
Faculty Of Pharmaceutical Sciences Hoshi University
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Sato Mitsutaka
Faculty Of Science And Technology Hirosaki University
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Kitano Manabu
Faculty Of Pharmaceutical Sciences Hoshi University
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Nagai Tsuneji
Faculty Of Pharmaceutical Sciences Hoshi University
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Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
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Machida Yoshiharu
Faculty Of Pharmaceutical Sciences Hoshi University
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