In Vivo Properties of the Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Pharmacokinetics and Antitumor Characteristics against P388 Leukemia and Sarcoma 180
スポンサーリンク
概要
- 論文の詳細を見る
Conjugates of mitomycin C (MMC) with estradiol benzoate and estradiol via glutaric acid, abbreviated to EB-glu-MMC and E-glu-MMC, respectively, as previously reported, were examined concerning their pharmacokinetic behaviors and antitumor effects against two kinds of general and popular tumors, P388 leukemia and Sarcoma 180. EB-glu-MMC and E-glu-MMC were dissolved in propylene glycol. Their solution was administered intrapertioneally to rats and mice in order to examine their plasma concentration-time profiles and antitumor characteristics, respectively. After the administraiton of EB-glu-MMC, EB-glu-MMC was detected slightly in blood only in the initial stage, while E-glu-MMC and MMC were observed there for a prolonged period. In the administration of E-glu-MMC, a similar phenomenon was observed but the drug retention effect seemed lower than that in EB-gul-MMC. In the antitumor test against P388 leukemia, E-glu-MMC exhibited a better effect than EB-glu-MMC; however, neither conjugate surpassed the effect of MMC. The toxic side effect was improved in each conjugate. As to the growth inhibition against Sarcoma 180,EB-glu-MMC and E-glu-MMC produced good effect and improved the toxic side effect. Especially, in the administration of EB-glu-MMC at the dose of 30 mg eq MMC/kg, a decrease in tumor volume was observed in the latter stage. EB-glu-MMC and E-glu-MMC were demonstarted to produce prolonged retention, to enter the systemic circulation to a fair extent, and to exhibit a good effect against the general solid tumor, Sarcoma 180,in vivo.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
-
Onishi Hiraku
Department Of Drug Delivery Research Hoshi University
-
Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
-
Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
-
Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
-
Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
-
ISHIKI Nobuyuki
Department of Drug Delivery Research, Hoshi University
-
Ishiki Nobuyuki
Department Of Drug Delivery Research Hoshi University
関連論文
- Preparation and Evaluation of Novel Directly-Compressed Fast-Disintegrating Furosemide Tablets with Sucrose Stearic Acid Ester
- Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent
- Preparation and Evaluation of Medicinal Carbon Tablets with Different Saccharides as Binders
- Medicinal Carbon Tablets for Treatment of Acetaminophen Intoxication : Adsorption Characteristics of Medicinal Carbon Powder and Its Tablets
- In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats(Biopharmacy)
- In Vivo Drug Release and Antitumor Characteristics of Water-Soluble Conjugates of Mitomycin C with Glycol-Chitosan and N-Succinyl-Chitosan
- Preparation and Drug Release Characteristics of the Conjugates of Mitomycin C with Glycol-chitosan and N-Succinyl-chitosan
- Preparation and Evaluation of the Macromolecular Conjugate of 2' or3'-(4-Carboxybutyryl)doxifluridine with Chitosan
- Influence of Flushing Conditions on Incompatibility in Y-site Injection (Second report) : Survey and Evaluation Flushing Conditions at Medical Institutions
- Enhancing Effect of Switching Iontophoresis on Transdermal Absorption of Sodium Benzoate In Vivo
- Biological Fate of Highly-Succinylated N-Succinyl-chitosan and Antitumor Characteristics of Its Water-soluble Conjugate with Mitomycin C at I.v. and I.p. Administration into Tumor-Bearing Mice
- Quantitative Evaluation for the Endotoxin Adsorption-Ability of Medicinal Carbon
- Antitumor Characteristics of Poly (d, l-lactic acid-co-glycolic acid) Copolymer Implant Tablets Containing Irinotecan Hydrochloride (CPT-11)
- Effect of Penetration Enhancers on Transdermal Delivery of Propofol(Biopharmacy)
- An Automatic Ampoule Dispensing System Improved Injection Dispensing
- PLGA Implant Tablet of Ketoprofen : Comparison of in Vitro and in Vivo Releases(Biopharmacy)
- Preparation of Quickly Disintegrating Glucose Tablets for Treatment of Hypoglycemia and Analysis of Factors Influencing the Characteristics of the Tablets
- Influence of Pectins on Preparation Characteristics of Lactoferrin Bioadhesive Tablets
- Preparation and Characterization of an Aqueous Suspension Containing Nanoparticles of Poly (DL-lactic Acid)/Irinotecan/Polyethylene Glycol Monostearate
- Prolonged Intestinal Absorption of Cephradine with Chitosan-Coated Ethylcellulose Microparticles in Rats
- Effect of Iontophoresis and Switching Iontophoresis on Skin Accumulation of Ketoprofen(Biopharmacy)
- Transdermal Absorption of Propofol in Rats(Biopharmacy)
- Biodisposition Characteristics of N-Succinyl-chitosan and Glycol-chitosan in Normal and Tumor-bearing Mice
- Preparation of Double Liposomes and Their Efficiency as an Oral Vaccine Carrier(Biopharmacy)
- Antitumor Properties of Irinotecan-Containing Nanoparticles Prepared Using Poly(DL-lactic acid) and Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(Biopharmacy)
- Antitumor Activities of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol via Glutaric Acid in Suspension Dosage Form(Biopharmacy)
- In Vivo Properties of the Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Pharmacokinetics and Antitumor Characteristics against P388 Leukemia and Sarcoma 180
- Biological Properties of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Their Stability Characteristics in Biological Media and Their Binding Abilities to Estrogen Receptor
- Conversion Characteristics of the Conjugates of Mitomycin C with Estradiol and Estradiol Benzoate in Various pH Media
- Stability of Spironolactone in Rat Plasma : Strict Temperature Control of Blood and Plasma Samples Is Required in Rat Pharmacokinetic Studies(Biopharmacy)
- Preparation and Evaluation of Medicinal Carbon Oral Films
- In Vitro and in Vivo Evaluation of Sustained Release Chitosan-Coated Ketoprofen Microparticles
- Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis