Medicinal Carbon Tablets for Treatment of Acetaminophen Intoxication : Adsorption Characteristics of Medicinal Carbon Powder and Its Tablets
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概要
- 論文の詳細を見る
Adsorption characteristics of medicinal carbon powder (JP 14) for acetaminophen were examined at 37℃ using conventional incubation in an attempt to obtain an effective oral dosage form. Hydroxypropyl cellulose (HPC) and maltitol (MT), being able to act as a binding agent, were tested as additives. Tablets of medicinal carbon were produced by the wet granulation method. The rate and extent of adsorption of the medicinal carbon powder were roughly similar in water, JP 14 1st fluid (pH 1.2) and JP 14 2nd fluid (pH 6.8). The relationship between concentrations of free and adsorbed acetaminophen indicated that the adsorption followed the Langmuir mode. The maximal adsorption of acetaminophen in water was 0.219g per gram medicinal carbon powder, little influenced by the addition of MT, but slightly reduced by the addition of HPC. The tablet prepared using MT as a binding agent displayed a favorable hardness and adequate disintegration time. The tablet showed good adsorption potential for acetaminophen, though the adsorption rate and extent of the tablet were reduced to some extent as compared with powder.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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ONISHI Hiraku
Department of Drug Delivery Research, Hoshi University
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MACHIDA Yoshiharu
Department of Drug Delivery Research, Hoshi University
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Ito Akihiko
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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YAMAMOTO Kenta
Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular
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Ito Akihiko
Inst. For Materials Res. Tohoku Univ.
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Ito Akihiko
Department of Medicinal Therapy Research, Meiji Pharmaceutical University
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Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
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Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
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Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
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Ito Akihiko
Department Of Chemical Engineering Tokyo University Of Agriculture And Technology
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Ito Akihiko
Department Of Biomedical Informatics Division Of Surgical Pathology Kobe University Graduate School
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Yamamoto Kenta
Department of Drug Delivery Research, Hoshi University
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