Biodisposition Characteristics of N-Succinyl-chitosan and Glycol-chitosan in Normal and Tumor-bearing Mice
スポンサーリンク
概要
- 論文の詳細を見る
Two water-soluble chitosan derivatives, N-succinyl-chitosan (Suc-chi; average MW 3×10^5) and glycol-chitosan (Gly-chi; average MW 1.5×10^5), were examined concerning their biodisposition characteristics in order to evaluate their possible use as water-soluble drug carriers. Their body distribution and urinary excretion were investigated by i.v. administration of FITC-labeled Suc-chi (FTC-Suc-chi) and FITC-labeled Gly-chi (FTC-Gly-chi) to normal and Sarcoma 180 solid tumor-bearing mice. In normal mice, both polymers showed good retention in blood circulation; especially, FTC-Suc-chi exhibited a long half-life of 51 h, and its distribution to other tissues was very small. FTC-Gly-chi was distributed into the kidney to a relatively high extent. In tumor-bearing mice, FTC-Suc-shi and FTC-Gly-chi were eliminated faster from the blood circulaiton than in normal mice, that is, with half-lives of 11 and 7h, respectively. FTC-Suc-chi was less partitioned to the tumor tissue but accumulated more easily into it compared with FTC-Gly-chi. This suggested the enhanced permeability and retention (EPR) effect of Suc-chi and explained the previous result that a water-soluble Suc-chi-mitomycin C conjugate injected intravenously exhibited a good effect against Sarcoma 180 solid tumor. FTC-Gly-chi showed greater distribution to the kidney than in normal mice. Urinary excretion studies indicated the faster excretion of both polymers in tumor-bearing mice. The molecular weight of the products excreted into urine indicated that both polymers should be pretty resistant to the hydrolytic enzyme, lysozyme. Taking toxicities into account, Suc-chi is consiered to be available as a drug carrier showing long systemic retention and tumor accumulation.
- 公益社団法人日本薬学会の論文
- 1999-02-15
著者
-
Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
-
Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
-
KAMIYAMA Kazuka
Department of Clinical Pharmacy, Hoshi University
-
Kamiyama Kazuka
Department Of Clinical Pharmacy Hoshi University
関連論文
- Preparation and Evaluation of Novel Directly-Compressed Fast-Disintegrating Furosemide Tablets with Sucrose Stearic Acid Ester
- Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent
- Preparation and Evaluation of Medicinal Carbon Tablets with Different Saccharides as Binders
- Medicinal Carbon Tablets for Treatment of Acetaminophen Intoxication : Adsorption Characteristics of Medicinal Carbon Powder and Its Tablets
- In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats(Biopharmacy)
- Influence of Flushing Conditions on Incompatibility in Y-site Injection (Second report) : Survey and Evaluation Flushing Conditions at Medical Institutions
- Enhancing Effect of Switching Iontophoresis on Transdermal Absorption of Sodium Benzoate In Vivo
- Biological Fate of Highly-Succinylated N-Succinyl-chitosan and Antitumor Characteristics of Its Water-soluble Conjugate with Mitomycin C at I.v. and I.p. Administration into Tumor-Bearing Mice
- Quantitative Evaluation for the Endotoxin Adsorption-Ability of Medicinal Carbon
- Antitumor Characteristics of Poly (d, l-lactic acid-co-glycolic acid) Copolymer Implant Tablets Containing Irinotecan Hydrochloride (CPT-11)
- Effect of Penetration Enhancers on Transdermal Delivery of Propofol(Biopharmacy)
- An Automatic Ampoule Dispensing System Improved Injection Dispensing
- PLGA Implant Tablet of Ketoprofen : Comparison of in Vitro and in Vivo Releases(Biopharmacy)
- Preparation of Quickly Disintegrating Glucose Tablets for Treatment of Hypoglycemia and Analysis of Factors Influencing the Characteristics of the Tablets
- Influence of Pectins on Preparation Characteristics of Lactoferrin Bioadhesive Tablets
- Preparation and Characterization of an Aqueous Suspension Containing Nanoparticles of Poly (DL-lactic Acid)/Irinotecan/Polyethylene Glycol Monostearate
- Prolonged Intestinal Absorption of Cephradine with Chitosan-Coated Ethylcellulose Microparticles in Rats
- Effect of Iontophoresis and Switching Iontophoresis on Skin Accumulation of Ketoprofen(Biopharmacy)
- Transdermal Absorption of Propofol in Rats(Biopharmacy)
- Biodisposition Characteristics of N-Succinyl-chitosan and Glycol-chitosan in Normal and Tumor-bearing Mice
- Preparation of Double Liposomes and Their Efficiency as an Oral Vaccine Carrier(Biopharmacy)
- Antitumor Properties of Irinotecan-Containing Nanoparticles Prepared Using Poly(DL-lactic acid) and Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(Biopharmacy)
- Antitumor Activities of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol via Glutaric Acid in Suspension Dosage Form(Biopharmacy)
- In Vivo Properties of the Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Pharmacokinetics and Antitumor Characteristics against P388 Leukemia and Sarcoma 180
- Biological Properties of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Their Stability Characteristics in Biological Media and Their Binding Abilities to Estrogen Receptor
- Conversion Characteristics of the Conjugates of Mitomycin C with Estradiol and Estradiol Benzoate in Various pH Media
- Stability of Spironolactone in Rat Plasma : Strict Temperature Control of Blood and Plasma Samples Is Required in Rat Pharmacokinetic Studies(Biopharmacy)
- Preparation and Evaluation of Medicinal Carbon Oral Films
- In Vitro and in Vivo Evaluation of Sustained Release Chitosan-Coated Ketoprofen Microparticles
- Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis