Quantitative Evaluation for the Endotoxin Adsorption-Ability of Medicinal Carbon
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概要
- 論文の詳細を見る
The therapy of mass alimentary intoxication caused by Salmonella and Enteropathogenic Escherichia coli is discussed. Endotoxin causes fervescence, disseminated intravascular coagulation or shock. When antibiotics are administered for the treatment of alimentary intoxication, toxicity of the endotoxin from the defluvium of bacillus mort body can cause serious symptoms. We noted the strong adsorption force of medicinal carbon and evaluated the endotoxin adsorption ability of medicinal carbon quantitatively using a chromogenic endotoxin specific assay quantitatively. Methods for evaluating damage due to the oral invasion of endotoxin have hardly been developed. The presence of alimentary intoxication due to a large quantity of endotoxin in intestine was assumed, and an in vivo test was performed to evaluate the endotoxin adsorption ability of medicinal carbon based on the influence of particle size. An in vitro test showed the adsorption coefficient to increase with the reaction times of medicinal carbon and endotoxin. The quantity of adsorption of endotoxin decreased as the particle size of medicinal carbon increased. As in vivo test showed that a change in the body temperature of mouse, which is an index of the physiological activity of endotoxin, was reduced by the oral administration of medicinal carbon. Consisting of small sized particies is thus considered to have a useful synergistic effect on the antibiotic treatment of food poisoning.
- 日本医療薬学会の論文
- 2001-02-10
著者
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TAKAHASHI Yuri
Department of Drug Delivery Research, Hoshi University
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MACHIDA Yoshiharu
Department of Drug Delivery Research, Hoshi University
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Ito Akihiko
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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Ito Akihiko
Inst. For Materials Res. Tohoku Univ.
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Iwata Masanori
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine Tohyoko Hospital
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Takahashi Toyozo
Department of Bacteriology, Yokohama City University School of Medicine
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Ito Akihiko
Pharmaceutical Department, Tokyo Women's Medical College
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Iwata Masanori
Department Of Pharmacy Yokohama City University Medical Center
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Iwata Masanori
Department Of Obstetrics And Gynecology St. Marianna University School Of Medicine Tohyoko Hospitall
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Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
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Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
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Takahashi Yuri
Department Of Bioresource Engineering Faculty Of Agriculture Yamagata University
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Takahashi Toyozo
Department Of Bacteriology Yokohama City University School Of Medicine
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Ito Akihiko
Pharmaceutical Department Tokyo Women's Medical University
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Takahashi Yuri
Department of Pharmacy, Sapporo City General Hospital
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