The Effect of Dried Aluminum Hydroxide Gel on the Blood Concentration of Cyclosporine-A
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概要
- 論文の詳細を見る
The blood concentrations of cyclosporine-A (CyA) decreased remarkably in a pediatric patient who had been administered CyA combined with dried aluminum hydroxide gel (DALG). The difference in the ratio of the dosage per body weight to the blood concentrations of CyA was remarkable in patients who underwent CyA immunosuppressive therapy either with DALG (n=25) or without DALG (n=21). The ratio was 15.6 ± 8.9 (mean±standard deviation) in patients with DALG and 25.9 ±15.4 in those without DALG. After adding DALG to an in vitro pH 1.2 CyA solution, the solution became turbid and the concentration of CyA in the supernatant decreased by about 20 percent compared to the control without DALG. In rats, the area under the curve (AUC) of CyA with DALG was 17 percent lower than that of CyA alone. These findings indicate that the blood concentrations of CyA are affected by administration with DALG, and that aluminum hydroxide gel decreases the absorption of CyA by adsorption or complex formation.
- 日本医療薬学会の論文
- 1997-10-10
著者
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Suzuki Ryoko
Departments Of Surgery Ii Faculty Of Medicine Kochi University
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Suzuki Ryoko
Department Of Biomolecular Science Faculty Of Science Toho University
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Matsumoto Mitsuo
Department of Pharmaceutics, Showa Pharmaceutical University
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SHIROTAKE Shoichi
Department of Pharmacy, Yokohama City University Hospital
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Shirotake Shoichi
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Mitsuo
Department Of Pharmaceutics Showa Pharmaceutical University
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Murata Masahiro
Department Of Pharmacy Services Tama Nagayama Hospital Nippon Medical School
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Iwata Masanori
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine Tohyoko Hospital
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Watanabe Yoshiteru
Showa Pharmaceutical Univ.
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MATSUYAMA Shusuke
Department of Pediatrics, Yokohama City University, School of Medicine
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ICHISAWA MASAYUKI
Department of Pharmacy, Yokohama City University Hospital
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OHTA ICHIRO
Department of Pharmacy, Yokohama City University Hospital
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Ichisawa Masayuki
Department Of Pharmacy Yokohama City University Hospital
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Iwata Masanori
Department Of Obstetrics And Gynecology St. Marianna University School Of Medicine Tohyoko Hospitall
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Matsuyama Shusuke
Department Of Pediatrics Yokohama City University School Of Medicine
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Matsumoto Mitsuo
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Ohta Ichiro
Department Of Obstetrics Gynecology And Molecular Reproductive Science Yokohama City University Grad
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Ohta Ichiro
Department Of Pharmacy Yokohama City University Hospital
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Suzuki Ryoko
Department Of Pharmacy Yokohama City University Hospital
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Shiraishi Shuji
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Mitsuo
Department Of Ophthalmology Hirosaki University School Of Medicine
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MATSUYAMA SHUSUKE
Department of Pediatrics, Yokohama City University School of Medicine
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Matsumoto Mitsuo
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University
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