Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG
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概要
- 論文の詳細を見る
To determine the effectiveness of human chorionic gonadotropin (hCG) administered rectally, we studied the pharmacokinetics and pharmacodynamics of hCG using a hollow-type suppository. HCG was not detected in plasma when only hCG was administered rectally, even at a higher dose (4000 IU/kg body weight) than intravenous injection, because of its low bioavailability due to high molecular weight or degradation by proteolytic activity. To enhance the rectal absorption of hCG, the effectiveness of its coadministration with α-cyclodextrin (α-CyD), an absorption-enhancing agent, was investigated in male rabbits. HCG was detected in plasma following coadministration of hCG and α-CyD (10 mg/kg body weight) into the rectum. The plasma hCG concentration increased with increasing dose of α-CyD. The AUC_<0→48> observed after coadministration of hCG and α-CyD at 30 mg/kg body weight was approximately four times higher than that of hCG and α-CyD at 10 mg/kg body weight. HCG at a high concentration induced a rapid increase in the plasma testosterone concentration (74.2±3.4 ng/ml) 2 h after intravenous administration. However, the testosterone concentration 24 h after intravenous administration decreased to the physiological level (approximately 20 ng/ml) which had been observed before such administration. On the other hand, the maximum level of testosterone concentration (40.0±12.6 ng/ml) was observed 24 h after rectal administration of hCG (400 IU/kg body weight) in combination with α-CyD (30 mg/kg body weight). Moreover, the plasma testosterone concentration (31.0±11.4 ng/ml) obtained 72 h after rectal administration tended to be maintained at a higher level than that (14.4±0.9 ng/ml) observed before the administration. These results suggest that the hollow-type suppository as a rectal delivery system of hCG is promising as a new mode of hCG therapy.
- 公益社団法人日本薬学会の論文
- 2002-05-01
著者
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Fujii Makiko
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Fujii Makiko
Showa Pharmaceutical Univ.
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Fujii Makiko
Department Of Chemistry Faculty Of Engineering Gifu University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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UTOGUCHI Naoki
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Watanabe Y
Showa Pharmaceutical Univ.
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Hirosawa Iori
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Fujii M
Showa Univ. Tokyo Jpn
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Watanabe Yoshiteru
Showa Pharmaceutical Univ.
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Utoguchi Naoki
Department Of Biopharmaceutics School Of Pharmaceutical Sciences Teikyo University
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Kowari Kouji
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Kurai Hirono
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Kowari Kouji
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Kurai Hirono
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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