EFFECTS OF ROSE BENGAL ON SERUM LEVELS OF THYROID HORMONES AND THYROID PEROXIDASE ACTIVITY IN MALE MICE.

スポンサーリンク

概要

• 論文の詳細を見る

• The thyrotoxic effect of Rose bengal (RB) (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; Food Red No. 105) was examined in male (C57BL/6N × C3H/N) F_1 mice. They were given drinking-water containing RB at levels of 0 (control), 0.125 and 0.250% for 2 weeks. The effect resulted in decreases in serum levels of 3,5,3'-triiodothyronine (T_3) and thyroxine (T_4), and slight increases in serum 3,3',5'-triiodothyronine (rT_3) levels and thyroid weight, but no difference in the values for the body-weight gain, serum thyroid stimulating hormone (TSH) levels and thyroid peroxidase (TPO) activities. However, the in vitro inhibitory effect of RB on TPO activity was observed by addition of RB to the TPO-catalyzed guaiacol oxidation. These results suggest that RB might have weak goitrogenic properties, inhibiting the peripheral conversion of T_4 to T_3 and/or inhibiting TPO to lead a decrease of T_4 and T_3 formation.

• 日本トキシコロジー学会の論文
• 1988-05-25

著者

• Nishimaki-mogami Tomoko

  国立医薬品食品衛生研究所 生物薬品部

• Nishimaki-mogami Tomoko

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Fujii M

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• KUREBAYASHI Hideo

  Division of Medical Chemistry, National Institute of Hygienic Sciences

• FUKUOKA Masamichi

  Division of Medical Chemistry, National Institute of Hygienic Sciences

• MINEGISHI Ken-ichiro

  Division of Medical Chemistry, National Institute of Hygienic Sciences

• TANAKA Akira

  Division of Medical Chemistry, National Institute of Hygienic Sciences

• Kurebayashi Hideo

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Fukuoka Masamichi

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Fukuoka Masamichi

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Fukuoka M

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Tanaka A

  Department Of Physics Kagoshima University

• Minegishi Ken-ichiro

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Tanaka Akira

  Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences

• Nishimaki-Mogami Tomoko

  Division of Functional Biochemistry and Genomics, National Institute of Health Sciences

• TANAKA Akira

  Department of Physics, Kagoshima University

関連論文

• Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
• Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation
• EFFECTS OF ROSE BENGAL ON SERUM LEVELS OF THYROID HORMONES AND THYROID PEROXIDASE ACTIVITY IN MALE MICE.
• Synthesis of Squamostanal-A
• Synthesis of Two Possible Diastereoisomers of the Epoxy Lactone Proposed for Epoxyrollin A
• Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
• COMPARISON OF TOXICITY TO PLANTS AMONG Al^, AlSO_4^+, AND Al-F COMPLEX IONS
• Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
• Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
• Determination of concentrations of flecainide in human serum by high-performance liquid chromatography on a fluorocarbon-bonded silica gel column
• 4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
• Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
• Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes
• Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
• Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
• A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
• Fast Parameter Selection Algorithm for Linear Parametric Filters(Digital Signal Processing)
• Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose(PH-M-06)and Spherical Sugar Granules
• Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose(PH-M Series)and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method
• Preparation of Griseofulvin for Topical Application Using N-Methyl-2-pyrrolidone
• A Unified Framework of Subspace Identification for D.O.A. Estimation(Engineering Acoustics)
• The Family of Regularized Parametric Projection Filters for Digital Image Restoration
• Study on the Discrepancy in Responses Given by Patients to Questions Regarding Subjective Symptoms
• Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan
• A High-Performance Liquid Chromatographic Determination of Cibenzoline Using Solid-Phase Extraction
• Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells
• Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
• Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
• In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
• Evaluation of Yucatan Micropig Skin for Use as an in Vitro Model for Skin Permeation Study
• Out-of-Plane Measurement of the ^Cu (e,e'p_0) Reaction in the Giant Resonance Region
• "B-2 Metabolic Study of Tris(2-Chloroethyl) Phosphate (TCEP) in vivo and in vitro.
• Population Pharmacokinetic Parameters of Valproic Acid ; Conventional and Slow Release Formulation
• Development of a Computer Program, MDGP, for Population Pharmacokinetic Analysis Written Using ANSI C Language on Wide Platforms
• Pharmacokinetics of Propofol Infusions in Japanese Patients
• Back Propagation Learning Using a Super Stable Motion
• Disposition and Metabolism of 2-Nitro-p-cresol in Rats and Its Effect on Hepatic Ornithine Decarboxylase (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
• Mechanism of Testicular Damage by Phthalic Acid Esters (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
• Possible Origin of Testicular Damage by Phthalic Acid Esters (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
• Responsiveness of Rat Nonparenchymal Liver Cells and Spleen Cells to the Decomposition of Erythrocytes Exposed to Di-n-butyl Phthalate and Its Metabolite
• Regulation of Inhibin β Chains and Follistatin mRNA Levels During Rat Hepatocyte Growth Induced by the Peroxisome Proliferator Di-n-butyl Phthalate
• Possible Origin of Testicular Atrophy Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
• Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG
• Lipase-catalyzed Asymmetric Synthesis of Enantiomerically Pure (2S, 4aS, 8S)-4a, 8-Dimethyl-2,3,4,4a, 5,6,7,8-octahydro-2-naphthalenol
• Application of the AMeX method to the evaluation of HER-2 status in breast carcinomas: Comparison with the results of HercepTest
• New Host Records of Ichneumonidae(Hymenoptera), with Description of a New Eriborus Species from Japan(VIII)
• Search for Lens-Aldose-Reductase Inhibitor in Medicinal Plants
• A Rare Case of Asymptomatic Diffuse Pulmonary Ossification Detected during a Routine Health Examination
• Parametric Wiener Filter with Linear Constraints for Unknown Target Signals
• Synthesis of Corticotropin Peptides. XI Synthesis and Biological Properties of [1-β-Alanine]-ACTH(1-18)-Octadecapeptide Amide
• Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A3*1 (213Arg) and ST1A3*2 (213His), Both of Which Exist in Japanese as Well as Caucasians.

もっと見る 閉じる

スポンサーリンク