Lipase-catalyzed Asymmetric Synthesis of Enantiomerically Pure (2S, 4aS, 8S)-4a, 8-Dimethyl-2,3,4,4a, 5,6,7,8-octahydro-2-naphthalenol

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概要

• 論文の詳細を見る

• Enantiomerically pure (2S, 4aS, 8S)-(+)-4a, 8-dimethyl-2,3,4,4a, 5,6,7,8-octahydro-2-naphthalenol (3), a key intermediate in the synthesis of natural geosmin (1), was prepared by enzymatic kinetic resolution. When racemic 3 was submitted to lipase (PS-30)-catalyzed asymmetric acetylation, employing vinyl acetate as the acyl donor, requisite product (+)-3 with a high enantiomeric excess was attained as the remaining alcohol. Recrystallization resulted in an enantiomerically pure sample.

• 社団法人日本農芸化学会の論文
• 1998-12-23

著者

• TANAKA Akira

  Division of Medical Chemistry, National Institute of Hygienic Sciences

• Saito A

  Yamaguchi Univ. Yamaguchi Jpn

• Tokuyama Takahito

  Division Of Life Science Graduate School Of Agricultural Science Tohoku University

• SAITO Akiko

  Division of Environmental Bioremediation

• ORITANI Takayuki

  Division of Life Science, Graduate School of Agricultural Science, Tohoku University

• Oritani Takayuki

  Division Of Life Science Graduate School Of Agricultural Science Tohoku University

• Tanaka Akira

  Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences

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