Search for Lens-Aldose-Reductase Inhibitor in Medicinal Plants
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概要
- 論文の詳細を見る
The MeOH extracts of 99 medicinal plants and crude drugs were tested for their effect on rabbit lens aldose reductase. Of these samples tested, 12 samples showed very strong inhibition and 7 samples showed fairly strong inhibition of rabbit lens aldose reductase. From the active fraction of the extract of Rhei Rhizoma, emodin and sennoside A were isolated, and they were found to have the activity comparable to that of quercetin, which is a known aldose reductase inhibitor (IC_<50> = 7.8×10^<-7> M).
- 日本生薬学会の論文
- 1987-12-20
著者
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TANAKA Akira
Division of Medical Chemistry, National Institute of Hygienic Sciences
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Takeda Osamu
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Tanimoto Tsuyoshi
Division Of Drug Evaluation National Institute Of Health Sciences
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FUJIOKA NAOMI
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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Kohda Hiroshi
Institute Of Pharmaceutical Science Hiroshima University Of Medicine
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KANDA NANA
Division of Biological Chemistry and Reference Standards, National Institute of Hygienic Sciences
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Kanda Nana
Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences
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Fujioka Naomi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Tanimoto Tsuyoshi
Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences
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Tanaka Akira
Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences
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Kohda Hiroshi
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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TAKEDA OSAMU
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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