Synthesis and Aldose Reductase-Inhibitory Activity of Imidazopyrroloquinoline Esters
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概要
- 論文の詳細を見る
Derivatives of imidazopyrroloquinoline (IPQ) and its esters were synthesized. Some of these compounds potently inhibited aldose reductases of rabbit lens and dog kidney, as well as the human recombinant enzyme, though the coenzyme pyrroloquinoline quinone (PQQ) was a relatively poor inhibitor. The IPQ esters with a methyl substituent at the C-3 carboxyl group were less potent inhibitors than the analogs without esterification at this position. An IPQ ester with the free carboxyl group at C-3 inhibited sorbitol accumulation in rat red blood cells.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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Niki E
Univ. Tokyo Tokyo Jpn
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Niki Etsuo
Research Center For Advanced Science And Technology The University Of Tokyo
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Niki Etsuo
Research Center For Advanced Science And Technolgy University Of Tokyo
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TANIMOTO Tsuyoshi
Division of Drug Evaluation, National Institute of Health Sciences
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Urakami T
Mitsubishi Gas Chemical Co. Tokyo Jpn
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Urakami Teizi
Biochemical Division Mitsubishi Gas Chemical Co.
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Tanaka Akinobu
Niigata Research Laboratory Mitsubishi Gas Chemical Co.
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Tanimoto T
National Inst. Health Sci. Tokyo Jpn
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Tanimoto Tsuyoshi
Division Of Drug Evaluation National Institute Of Health Sciences
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Urakami Teizi
Biochemicals Division Mitsubishi Gas Chemical Co.:research Center For Advanced Science And Technolog
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Tanimoto Tsuyoshi
Division Of Biological Chemistry And Reference Standards National Institute Of Hygienic Sciences
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