THE INHIBITORY EFFECT OF METHANOL ON FORSKOLIN-ACTIVATED ADENYLATE CYCLASE IN RAT ERYTHROCYTE MEMBRANES DEPENDENT ON THE STATE OF THE GUANINE NUCLEOTIDE-BINDING STIMULATORY AND REGULATORY PROTEIN
スポンサーリンク
概要
- 論文の詳細を見る
Forskolin-activated adenylate cyclase activity in rat erythrocyte membranes was markedly inhibited by methanol in a concentration dependent manner. On the contrary, no change was observed in the basal cyclase activity in the presence of methanol. The methanol inhibition forskolin-activated cyclase activity was protected by the stimulation of Gs in the presence of NaF in a concentration dependent manner. These data indicate that low-and high-affinity binding sites of forskolin in rat erythrocyte membranes have different sensitivities to methanol.
- 公益社団法人日本薬学会の論文
著者
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KOHDA Hiroshi
Institute of Pharmaceutical Sciences, School of medicine, Hiroshima University
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Yamasaki Kazuo
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Yamashita A
Hiroshima Univ. Hiroshima Jpn
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Yamashita Atsushi
Department Of Mechanical Engineering Shizuoka University
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Yamashita Atsushi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Yamashita Atsushi
Department Of Fixed Prosthodontics Okayama University Dental School
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Yamasaki Kazuo
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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Takeda O
Hiroshima Univ. School Of Medicine Hiroshima Jpn
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Higashi K
Rohto Pharmaceutical Co. Ltd. Osaka Jpn
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Kohda Hiroshi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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TAKEDA Osamu
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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KUROKAWA Tomonori
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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ISHIBASHI Sadahiko
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Yamashita A
Department Of Mechanical Engineering Shizuoka University
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Yamashita A
Tohoku Univ. Sendai Jpn
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Takeda Osamu
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Ishibashi S
Hiroshima Univ. Hiroshima Jpn
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Kurokawa T
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Yamashita Atsushi
Department Of Metallurgy Graduate School Of Engineering Tohoku University
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Kohda Hiroshi
Institute Of Pharmaceutical Science Hiroshima University Of Medicine
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YAMASAKI Kazuo
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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