CHARACTERIZATION OF HETEROLOGOUS DESENSITIZATION OF RAT RETICULOCYTE ADENYLATE CYCLASE SYSTEM
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概要
- 論文の詳細を見る
Treatment of rat reticulocytes with isoproterenol caused about 50,25,and 25% decreases in β-adrenergic agonist-, fluoride-, and guanine nucleotide-stimulated adenylate cyclase activities, respectively. The desensitization was also induced by dibutyryl adenosine 3', 5'-cyclic monophosphate (cyclic AMP) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented the isoproterenol-induced desensitization, suggesting the involvement of cyclic AMP in the desensitization. Time course studies revealed that the desensitization to NaF-AlCl_3 occurred faster than that to isoproterenol. Furthermore, the rate of the resensitization to NaF-AlCl_3 by removal of isoproterenol was also faster than that to isoproterenol. Thus, it is likely that both guanine nucleotide-binding stimulatory regulatory protein, N_s, and β-adrenergic receptor are sequentially involved in both desensitization and resensitization of the adenylate cyclase system in rat reticulocytes to isoproterenol.
- 公益社団法人日本薬学会の論文
著者
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Yamashita Atsushi
Department of Pathology, Faculty of Medicine, University of Miyazaki
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Yamashita A
Hiroshima Univ. Hiroshima Jpn
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Yamashita Atsushi
Department Of Mechanical Engineering Shizuoka University
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Yamashita Atsushi
Department Of Electrical Engineering Faculty Of Engineering Kyoto University:(present Address) Nec C
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Yamashita Atsushi
Department Of Fixed Prosthodontics Okayama University Dental School
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ISHIBASHI Sadahiko
Department of Physiological Chemistry, Hiroshima University School of Medicine
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KUROKAWA Tomonori
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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DANURA TOSHIO
Department of Physiological Chemistry, Hiroshima University School of Medicine
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KUROKAWA TOMONORI
Department of Physiological Chemistry, Hiroshima University School of Medicine
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YANAGIUCHI HIDEMI
Department of Physiological Chemistry, Hiroshima University School of Medicine
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Yamashita A
Department Of Mechanical Engineering Shizuoka University
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Yamashita A
Tohoku Univ. Sendai Jpn
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Ishibashi S
Hiroshima Univ. Hiroshima Jpn
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Ishibashi Sadahiko
Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University
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Danura Toshio
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Kurokawa T
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Kurokawa Tomonori
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Yamashita Atsushi
Department Of Metallurgy Graduate School Of Engineering Tohoku University
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Yamashita Atsushi
Department Of Agricultural Chemistry Tottori University
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Yanagiuchi Hidemi
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Dan'ura Toshio
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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