CHARACTERIZATION OF HETEROLOGOUS DESENSITIZATION OF RAT RETICULOCYTE ADENYLATE CYCLASE SYSTEM

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概要

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• Treatment of rat reticulocytes with isoproterenol caused about 50,25,and 25% decreases in β-adrenergic agonist-, fluoride-, and guanine nucleotide-stimulated adenylate cyclase activities, respectively. The desensitization was also induced by dibutyryl adenosine 3', 5'-cyclic monophosphate (cyclic AMP) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented the isoproterenol-induced desensitization, suggesting the involvement of cyclic AMP in the desensitization. Time course studies revealed that the desensitization to NaF-AlCl_3 occurred faster than that to isoproterenol. Furthermore, the rate of the resensitization to NaF-AlCl_3 by removal of isoproterenol was also faster than that to isoproterenol. Thus, it is likely that both guanine nucleotide-binding stimulatory regulatory protein, N_s, and β-adrenergic receptor are sequentially involved in both desensitization and resensitization of the adenylate cyclase system in rat reticulocytes to isoproterenol.

• 公益社団法人日本薬学会の論文

著者

• Yamashita Atsushi

  Department of Pathology, Faculty of Medicine, University of Miyazaki

• Yamashita A

  Hiroshima Univ. Hiroshima Jpn

• Yamashita Atsushi

  Department Of Mechanical Engineering Shizuoka University

• Yamashita Atsushi

  Department Of Electrical Engineering Faculty Of Engineering Kyoto University:(present Address) Nec C

• Yamashita Atsushi

  Department Of Fixed Prosthodontics Okayama University Dental School

• ISHIBASHI Sadahiko

  Department of Physiological Chemistry, Hiroshima University School of Medicine

• KUROKAWA Tomonori

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• DANURA TOSHIO

  Department of Physiological Chemistry, Hiroshima University School of Medicine

• KUROKAWA TOMONORI

  Department of Physiological Chemistry, Hiroshima University School of Medicine

• YANAGIUCHI HIDEMI

  Department of Physiological Chemistry, Hiroshima University School of Medicine

• Yamashita A

  Department Of Mechanical Engineering Shizuoka University

• Yamashita A

  Tohoku Univ. Sendai Jpn

• Ishibashi S

  Hiroshima Univ. Hiroshima Jpn

• Ishibashi Sadahiko

  Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University

• Danura Toshio

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Kurokawa T

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• Kurokawa Tomonori

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Yamashita Atsushi

  Department Of Metallurgy Graduate School Of Engineering Tohoku University

• Yamashita Atsushi

  Department Of Agricultural Chemistry Tottori University

• Yanagiuchi Hidemi

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Dan'ura Toshio

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

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