INHIBITION OF SUPEROXIDE ANION PRODUCTION IN GUINEA PIG POLYMORPHONUCLEAR LEUKOCYTES BY A SELENO-OR-GANIC COMPOUND, EBSELEN
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概要
- 論文の詳細を見る
Production of superoxide anion (O^-_2) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3 (2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O^-_2 production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.
- 公益社団法人日本薬学会の論文
著者
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Ohtsuka Toshiaki
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Ohtsuka Toshiaki
Department Of Applied Chemistry Nagoya Institute Of Technology
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OKAMURA Naoki
Department of Physiological Chemistry, Hiroshima University School of Medicine
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ISHIBASHI Sadahiko
Department of Physiological Chemistry, Hiroshima University School of Medicine
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Okamura N
Hiroshima Univ. Hiroshima Jpn
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Okamura Naoki
Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University
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Ishibashi S
Hiroshima Univ. Hiroshima Jpn
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Ichikawa Shigemi
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Ishibashi Sadahiko
Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University
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MASAYASU Hiroyuki
Daiichi Pharmaceutical Co., Ltd.
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OMURA KAZUE
Department of Physiological Chemistry, Hiroshima University School of Medicine
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KATAYAMA TERUAKI
Department of Physiological Chemistry, Hiroshima University School of Medicine
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MASAYASU HIROYUKI
Department of Physiological Chemistry, Hiroshima University School of Medicine
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Omura Kazue
Department Of Physiological Chemistry Hiroshima University School Of Medicine:research Institute Dai
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Katayama Teruaki
Department Of Physiological Chemistry Hiroshima University School Of Medicine:research Institute Dai
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Masayasu H
Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn
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