Sphingosine Inhibition of NADPH Oxidase Activation in a Cell-Free System.
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概要
- 論文の詳細を見る
The effects of sphingoid bases, sphingosine and dihydrosphingosine, which are protein kinase C (PKC) inhibitors, on NADPH oxidase were examined in a cell-free system. The bases inhibited cell-free activation of NADPH oxidase by arachidonic acid at lower concentration than N-acetylsphingosine. Thus, positive charge in the molecules may play a critical role in inhibition of the oxidase. Sphingosine did not change the Km value for NADPH, but shifted the optimum concentration of arachidonic acid for activation of the oxidase. Moreover, sphingosine suppressed the translocation of p47-phox, one of the cytosolic components of the oxidase, to the membrane fraction, suggesting that the base inhibits the assembly of the components.
- 社団法人 日本生化学会の論文
著者
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Yamaguchi Masafumi
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Sasaki Jun-ichi
Department Of Physics Sophia University
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Saeki Satoshi
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Yamane Hana
Department Of Physiological Chemistry Hiroshima University School Of Medicine
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Okamura Naoki
Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University
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Ishibashi Sadahiko
Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University
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Sasaki Jun-ichi
Department of Physiological Chemistry, Hiroshima University School of Medicine
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