Sphingosine Inhibition of NADPH Oxidase Activation in a Cell-Free System.

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of sphingoid bases, sphingosine and dihydrosphingosine, which are protein kinase C (PKC) inhibitors, on NADPH oxidase were examined in a cell-free system. The bases inhibited cell-free activation of NADPH oxidase by arachidonic acid at lower concentration than N-acetylsphingosine. Thus, positive charge in the molecules may play a critical role in inhibition of the oxidase. Sphingosine did not change the Km value for NADPH, but shifted the optimum concentration of arachidonic acid for activation of the oxidase. Moreover, sphingosine suppressed the translocation of p47-phox, one of the cytosolic components of the oxidase, to the membrane fraction, suggesting that the base inhibits the assembly of the components.

• 社団法人 日本生化学会の論文

著者

• Yamaguchi Masafumi

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Sasaki Jun-ichi

  Department Of Physics Sophia University

• Saeki Satoshi

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Yamane Hana

  Department Of Physiological Chemistry Hiroshima University School Of Medicine

• Okamura Naoki

  Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University

• Ishibashi Sadahiko

  Department Of Physiological Chemistry Faculty Of Medicine Hiroshima University

• Sasaki Jun-ichi

  Department of Physiological Chemistry, Hiroshima University School of Medicine

関連論文

• Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation
• Slowly Progressive Adenocarcinoma of the Lung : Report of a Case
• Rib Metastasis Appearing 8 Years After Surgery for Lung Cancer : Report of a Case
• Raman Scattering in the Inorganic Spin-Peierls System α'-Na_V_2O_5
• Thoracoscopic Treatment of Bochdalek Hernia in the Adult : Report of a Case
• Favorable Surgical Results for Patients with Nonsmall Cell Lung Cancer over 80 Years Old : A Multicenter Survey
• Intrapleural Hypotonic Cisplatin Treatment for Malignant Pleural Mesothelioma : In Vitro Experiments and Clinical Application
• Resection of Radiation-Induced Sarcoma of the Clavicle
• Extension of Liver Tissue into the Thorax Following a Right Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
• Thoracoscopic Surgery Combined with a Supraclavicular Approach for Removing a Cervico-Mediastinal Neurogenic Tumor : A Case Report
• Surgical Treatment of Neurogenic Tumors of the Chest
• Radiation Resistant Low Bandgap InGaASP Solar Cell for Multi-Junction Solar Cells : Semiconductors
• Effects of Annealing on Type Converted Si and Space Solar Cells Irradiated with Heavy Fluence 1 MeV Electrons
• Analysis of Radiation Damage to Si Solar Cells under High-Fluence Electron Irradiation
• Conformational Analysis by IR and Birefringence Measurements for Poly(B-phenylpropyl L-aspartate)Exhibiting a Helical Sense Inversion in the Solid State
• Folded Phonon Mode Observed by Raman Scattering in Zn- and Si-Doped CuGeO_3
• Decavanadate Inhibits the Cell-Free Activation of Neutrophil NADPH Oxidase without Affecting Tyrosine Phosphorylation
• Sphingosine Inhibition of NADPH Oxidase Activation in a Cell-Free System
• Differences in Mechanisms for Cell-Free NADPH Oxidase Activation between Arachidonate and Sodium Dodecyl Sulfate
• Room-Temperature Annealing Effects on Radiation-Induced Defects in InP Crystals and Solar Cells
• High-Efficiency InP Solar Cells with n^+-p-p^+ Structure Grown by Metalorganic Chemical Vapor Deposition
• Impurity Concentration Effects on Radiation Defect Introduction in InP Examined by in situ Measurement
• Electron Irradiation Damage in Radiation-Resistant InP Solar Cells
• Optical Damage in Fe-Doped LiNbO_3
• Optical Damage in LiNbO_3 Inducedby X-ray Irradiation
• Electron Hall Mobility in Reduced LiNbO_3
• Proton Irradiation Damage in GaAs Single Crystals Examined for Solar Cells
• Surface Field Effect of Photoluminescence Intensity in ZnSe Schottky Diode
• Thymoma Arising in a Thymic Cyst
• Pulmonary Metastasis with an Endobronchial Growth Pattern : Report of a Case
• In situ Real-Time X-ray Reciprocal Space Mapping during InGaAs/GaAs Growth for Understanding Strain Relaxation Mechanisms
• The Use of a Water Seal to Manage Air Leaks after a Pulmonary Lobectomy : A Retrospective Study
• Investigation of High-Efficiency InGaP/GaAs Tandem Solar Cells under Concentration Operation
• Two-Terminal Monolithic In_Ga_P/GaAs Tandem Solar Cells with a High Conversion Efficiency of Over 30%
• Double Heterostructure GaAs Tunnel Junction for a AlGaAs/GaAs Tandem Solar Cell
• Surgical Outcome of an Anatomical Resection of Clinical Stage IA Non-Small Cell Lung Cancer Assisted with a Video-Thoracoscopy
• BRAIN ADENYLATE CYCLASE INHIBITION BY BENZODIAZEPINES
• CHARACTERIZATION OF HETEROLOGOUS DESENSITIZATION OF RAT RETICULOCYTE ADENYLATE CYCLASE SYSTEM
• INHIBITION OF BRAIN ADENYLATE CYCLASE BY BARBITURATES THROUGH THE EFFECT ON THE INTERACTION BETWEEN GUANINE NUCLEOTIDE-BINDING STIMULATORY REGULATORY PROTEIN AND CATALITIC UNIT
• INTERACTIONS BETWEEN VARIOUS LIGANDS IN THE ACTIVATION AND DESENSITIZATION OF ADENYLATE CYCLASE SYSTEM
• Properties of NADPH Oxidase in Specific Granule-Rich Fraction Prepared from Guinea Pig Neutrophils
• Spin-Peierls Gap and Two-Magnetic-Excitation Bound and Resonant States in Cu_Zn_xGeO_3 and CuGe_Si_yO_3
• Mechanism for the Inhibitory Effect of a Seleno-Organic Compound, Ebselen, and Its Analogues on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes
• INHIBITION OF SUPEROXIDE ANION PRODUCTION IN GUINEA PIG POLYMORPHONUCLEAR LEUKOCYTES BY A SELENO-OR-GANIC COMPOUND, EBSELEN
• DIFFERENCE BETWEEN MAGNESIUM AND MANGANESE IONS IN MODIFICATION OF EFFECT OF CATECHOLAMINE ON ADENYLATE CYCLASE SYSTEM IN EHRLICH ASCITES TUMOR CELLS
• Participation of Cytosolic Protein Phosphatase in Regulation of NADPH Oxidase in Polymorphonuclear Leukocytes
• Differences in the Expression of Glucose Transporter Protein Isoforms in Human Retinoblastoma Cell Lines
• ISOFORMS OF GLUCOSE TRANSPORTER IN THE IRIS-CILIARY BODY
• Intermittent Claudication Associated with Persistent Sciatic Artery:Report of Two Cases
• Behavior of Copper Impurity in ZnSe
• In_xGa_As Injection Lasers
• Ohmic Contacts to CdS
• Zinc Diffusion in In_xGa_As
• MODE OF INTERACTION BETWEEN FORSKOLIN AND MANGANESE ION IN ACTIVATING CATALYTIC UNIT OF ADENYLATE CYCLASE FROM RAT BRAIN
• A Complication of Thoracic Surgery : A Late-onset Chylomediastinum Resulting from a Left Upper Lobectomy and Lymph Node Dissection through a Median Sternotomy
• IN VITRO DEMONSTRATION OF DECREASED GLUCOSE OXIDATION IN BRAIN OF EXPERIMENTALLY DIABETIC RAT AND RECOVERY BY INSULIN
• Improving Crystallinity of Thin Si Film for Low-Energy-Loss Micro-/Nano-Electromechanical Systems Devices by Metal-Induced Lateral Crystallization Using Biomineralized Ni Nanoparticles (Special Issue : Applied Physics on Materials Research)
• The Mechanism of Insulin Action on Hexokinase Isozymes
• Involvement of the inhibitory GTP-binding regulatory protein and a low-affinity benzodiazepine receptor in the inhibitory effect of diazepam on rat brain adenylate cyclase system.
• Sphingosine Inhibition of NADPH Oxidase Activation in a Cell-Free System.

もっと見る 閉じる

スポンサーリンク