In Vitro Antioxidant Activity of Vietnamese Ginseng Saponin and Its Components
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概要
- 論文の詳細を見る
To elucidate the antioxidant action of Vietnamese ginseng saponin against free radial-mediated cellular damage, we examined the effect of Vietnamese ginseng saponin on lipid peroxidation in the mouse brain, liver, and liver microsomes by using two in vitro free radical generating systems (iron ferrous+ascorbic acid and iron ferrous+hydrogen peroxide). Free radical-mediated lipid peroxidation was determined by measuring the endogenous and stimulated accumulation of thiobarbituric acid reactive substance (TBA-RS). Vietnamese ginseng saponin (0.05-0.5 mg/ml), as well as vitamin E, significantly inhibited the formation of TBA-RS in tissue homogenates. Panax ginseng saponin, at the same concentration range as Vietnamese ginseng saponin, also had inhibitory action on free radical-mediated lipid peroxidation. However, majonoside-R2,ginsenoside Rg_1 and ginsenoside-Rb_1,the main saponin components of Vietnamese ginseng saponin fraction, had no effect on lipid peroxidation. These results suggest that Vietnamese ginseng exerts a protective action against free radical-induced tissue injury and that this effect is attributable to minor components rather than the main saponin components tested.
- 公益社団法人日本薬学会の論文
- 1998-09-15
著者
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山崎 勝也
大阪市立大学医学部生体情報解析学講座
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Huong N
Division Of Medicinal Pharmacology Institute Of Natural Medicines Toyama Medical And Pharmaceutical
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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Huong Nguyen
富山医科薬科大学和漢薬研究所
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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Yamasaki K
Faculty Of Pharmaceutical Sciences Teikyo Heisei University
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KASAI Ryoji
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Yamasaki K
Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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Yamasaki Kazuo
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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HOUNG Nguyen
Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical a
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Yamasaki Kazuo
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Kasai Ryoji
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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Watanabe H
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Huong Nguyen
Department Of Bioproduction And Environmental Science Faculty Of Agriculture Kyushu University
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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