Studies on Proton Pump Inhibitors. III. : Synthesis of 8-[(2-Benzimidazolyl)sulfinylmethyl]-1,2-dihydroquinolines and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
A series of 8-[(2-benzimidazolyl)sulfinylmethyl]-1,2-dihydroquinolines (XIIIa-g) was synthesized and tested for (H^+ + K^+) adenosine triphosphatase (ATPase)-inhibitory and antisecretory activities. These compounds were synthesized by the oxidation of sulfides, which were obtained from the reaction of 8-chloromethyl-1,2-dihydroquinolines (XIa-c) and 2-mercaptobenzimidazoles in the presence of sodium hydride. The key intermediates, 8-hydroxymethyl-1,2-dihydroquinolines (IVa-c), were perpared by the reduction-alkylation of 8-acetoxymethyl- or 8-hydroxymethylquinolines with sodium cyanoborohydride-formic acid. Among XIIIa-g, the 1,4-dimethyl-1,2-dihydroquinoline derivative (XIIIa) was found to have the highest activity.
- 社団法人日本薬学会の論文
- 1990-02-25
著者
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山崎 勝也
大阪市立大学医学部生体情報解析学講座
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山下 博司
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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中川 量之
2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.
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中川 量之
大塚製薬株式会社有機化学研究所
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中川 量之
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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中川 量之
大塚製薬株式会社徳島研究所
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薮内 洋一
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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藪内 洋一
大塚製薬徳島研究所
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Yamasaki K
Faculty Of Pharmaceutical Sciences Teikyo Heisei University
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内多 稔
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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森田 清司
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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神辺 敏実
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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山崎 勝也
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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千尋 正利
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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Morita S
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Uchida Masaki
Faculty Of Pharmaceutical Sciences Josai University
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Yamasaki K
Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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千壽 正利
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Uchida Masaatsu
Departments Of Pharmacology Meiji Pharmaceutical University
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神辺 敏実
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Uchida Mihoko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Morita S
Kagawa Medical Univ. Kagawa Jpn
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Uchida M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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Morita Shushi
Department Of Hospital Pharmacy Kagawa University
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森田 清司
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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薮内 洋一
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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千尋 正利
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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