5-(3-Aryloxypropyl)-1-cyclohexyltetrazole類の合成と血小板凝集抑制作用について

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概要

• 論文の詳細を見る

• A series of 5-(3-aryloxypropyl)-1-cyclohexyltetrazoles was synthesized and tested for inhibitory activity towards collagen- and adenosinediphosphate-induced aggregation of rabbit blood platelet in vitro. These compounds were prepared by the reaction of 1-cyclohexyl-5-(3-iodopropyl)-tetrazole with phenols in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl) propoxy]-1,3-dihydro-1-ethyl-2H-benzimidazol-2-one (IVd) was found to have potent inhibitory activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1984-02-25

著者

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 西 孝夫

  大塚製薬株式会社徳島第2工場医薬生産部

• 田房 不二男

  大塚製薬株式会社徳島研究所

• 田中 達義

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田中 達義

  大塚製薬株式会社, 徳島研究所

• 木村 征夫

  大塚製薬株式会社, 徳島研究所

• 木村 征夫

  大塚製薬株式会社医薬第一研究所

• 田中 達義

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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