Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. III. N-Cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)-butyramide and Related Compounds

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概要

• 論文の詳細を見る

• A series of N, N-disubstituted-ω-(1,2-dihydro-2-oxoquinolyloxy) alkanecarboxamides was synthesized and tested for inhibitory activity towards collagen- and ADP-induced aggregation of rabbit blood platelet in vitro. These compounds were prepared by the reaction of ω-(1,2-dihydro-2-oxoquinolyloxy) alkanoic acid and various amines by the mixed anhydride method. Among them, N-cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy) butyramide (IVa_1) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1983-03-25

著者

• 上田 敬

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 清水 剛文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 西 孝夫

  大塚製薬株式会社徳島第2工場医薬生産部

• 神辺 敏実

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 田房 不二男

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 西 孝夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 木村 征夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田中 達義

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 上田 敬

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 神辺 敏実

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 木村 征夫

  大塚製薬株式会社医薬第一研究所

• 田中 達義

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 上田 敬

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 清水 剛文

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

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