Synthesis and Antiulcer Activity of Optical Isomers of 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic Acid (Rebamipide)
スポンサーリンク
概要
- 論文の詳細を見る
The enantiomers of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid [(±)-1,rebamipide, OPC-12759], a new antiulcer agent that enhances mucosal resistance, were synthesized from optically active α-amino acid derivatives of 2(1H)-quinolinone. The key intermediates, α-amino acid derivatives, were prepared by asymmetric synthesis and optical resolution. The (+)-1 was about 1.7 times as potent as the (-)-isomer in antiulcer activity against ethanol-induced gastric ulcers.
- 社団法人日本薬学会の論文
- 1991-11-25
著者
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山崎 勝也
大阪市立大学医学部生体情報解析学講座
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清水 剛文
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Yamasaki K
Faculty Of Pharmaceutical Sciences Teikyo Heisei University
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内多 稔
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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森田 清司
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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神辺 敏実
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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山崎 勝也
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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大坪 健児
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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Morita S
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Uchida Masaki
Faculty Of Pharmaceutical Sciences Josai University
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Yamasaki K
Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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Uchida Masaatsu
Departments Of Pharmacology Meiji Pharmaceutical University
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神辺 敏実
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Uchida Mihoko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Morita S
Kagawa Medical Univ. Kagawa Jpn
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Uchida M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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Morita Shushi
Department Of Hospital Pharmacy Kagawa University
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大坪 健児
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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森田 清司
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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清水 剛文
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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