3-芳香環置換2-(4-Chlorobenzoylamino)propionic Acid誘導体の合成と抗潰瘍作用について

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概要

• 論文の詳細を見る

• A series of 3-aromatic ring substituted 2-(4-chlorobenzoylamino) propionic acids was synthesized and tested for antiulcer activity towards the acetic acid-induced gastric ulcer in the rat which is a model of a chronic ulcer. 2-(4-Chlorobenzoylamino) propionic acid derivatives were prepared by the reaction of halomethyl or methanesulfonyloxymethyl substituted aromatic compounds with diethyl 4-chlorobenzoylaminomalonate, or by the 4-chlorobenzoylation of α-amino acids. Among the propionic acid derivatives thus synthesized, α-(4-chlorobenzoylamino)-2,3-dihydro-2-oxo-1H-indole-3-propionic acid was found to have a potent antiulcer activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1985-11-25

著者

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 森田 誠治

  大塚製薬株式会社徳島工場第一研究所

• 内多 稔

  大塚製薬株式会社徳島工場第一研究所

• 小松 真

  大塚製薬(株)新薬第三研究所

• 内多 稔

  大塚製薬(株)徳島研究所

• 神辺 敏実

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 森田 誠治

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田房 不二男

  大塚製薬株式会社徳島研究所

• 小松 真

  大塚製薬株式会社徳島研究所

• 神辺 敏実

  大塚製薬株式会社徳島研究所

• 森田 誠治

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Masaatsu

  Departments Of Pharmacology Meiji Pharmaceutical University

• 神辺 敏実

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 内多 稔

  大塚製薬株式会社徳島工場

• 森田 誠治

  大塚製薬株式会社徳島工場第3研究所

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