Studies on Positive Inotropic Agents. I. Synthesis of 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone and Related Compounds

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概要

• 論文の詳細を見る

• Many (1-piperazinyl)-2 (1H)-quinolinone derivatives were synthesized and examined for positive inotropic activities on the canine heart. Among them, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone (XVIIb-1) was found to have a very potent activity.

• 社団法人日本薬学会の論文
• 1984-06-25

著者

• 薮内 洋一

  大塚製薬徳島研究所

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 小川 英則

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 山下 修司

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 薮内 洋一

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 富永 道明

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 楊 永雄

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 山下 修司

  大塚製薬徳島研究所

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

• 小川 英則

  大塚製薬(株)徳島新薬第二研究所

• 楊 永雄

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 薮内 洋一

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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