β-受容体遮断作用を有する8-アシルアミノ-3,4-ジヒドロカルボスチリル誘導体の合成

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概要

• 論文の詳細を見る

• Twenty one kinds of 8-acylamino-5-(2-hydroxy-3-substituted aminopropoxy)-3,4-dihydrocarbostyril derivatives were synthesized and their antagonistic activities on isoproterenol were examined. Several compounds having 3,4-dimethoxyphenethyl or 4-carbamoylphenoxyethyl moiety in 3-substituted amino group were found to have less antagonistic activity on isoproterenol than those with tert-butyl or isopropyl moiety in 3-substituted amino group, but showed relative higher selectivity for β_1-adrenoreceptors in the anesthetized dog.

• 公益社団法人日本薬学会の論文
• 1984-01-25

著者

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 大城 靖男

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 渡辺 耕三

  大塚製薬株式会社新薬開発本部開発部PGx室

• 渡辺 耕三

  大塚製薬株式会社徳島研究所

• 大城 靖男

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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