Syntheses and β-Adrenergic Blocking Activities of Carbostyril Derivatives

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概要

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• Many 5-(3-amino-2-hydroxypropoxy)-8-alkoxy and acyloxy-3,4-dihydrocarbostyrils and 5-(3-amino-2-hydroxypropoxy)-8-alkoxycarbostyrils were synthesized from 5,8-dihydroxy-3,4-dihydrocarbostyril, and their β-adrenergic blocking activities were examincd. Among them, 8-acetonyloxy-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril hydrochloride hydrate (IVh) was found to have potent β_1-selective adrenergic blocking activity.

• 社団法人日本薬学会の論文
• 1981-08-25

著者

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 富永 道明

  Laboratories of Medicinal Chemistry

• 利根 斉

  Laboratories of Medicinal Chemistry

• 中川 量之

  Laboratories of Medicinal Chemistry

• 高田 馨子

  Laboratories of Preclinical Research

• 星野 洋

  Laboratories of Preclinical Resaarch

• 渡辺 耕三

  Laboratories of Preclinical Research

• 星野 洋

  Laboratories Of Preclinical Research Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

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