Syntheses and β-Adrenergic Blocking Activities of the Optical Isomers of 8-Acetonyloxyl-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril

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概要

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• The optical isomers of 8-acetonlloxy-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril were prepared from the optically active epichlorhydrin, and their β-adrenergic blocking activities were examined. The (S) (-)-isomer was shown to be about 200 times more potent on atrial and 100 times more potent on tracheal preparations, and was also about 3 times more β_1-selective than the (R) (+)-isomer.

• 社団法人日本薬学会の論文
• 1981-08-25

著者

• 楊 永雄

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  Laboratories of Medicinal Chemistry

• 星野 洋

  Laboratories of Preclinical Resaarch

• 楊 永雄

  Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 星野 洋

  Laboratories Of Preclinical Research Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 楊 永雄

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  Laboratories Of Medicinal Chemistry Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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• Syntheses and β-Adrenergic Blocking Activities of the Optical Isomers of 8-Acetonyloxyl-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril

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