Synthesis of 5-(2-Amino-1-hydroxybutyl)-8-hydroxycarbostyril, One of the Major Metabolites of Procaterol

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概要

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• The two isomers of 5-(2-amino-1-hydroxybutyl)-8-hydroxycarbostyril (2), which is a major metabolite of procaterol, were synthesized.

• 社団法人日本薬学会の論文
• 1980-11-25

著者

• 楊 永雄

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  Laboratories of Medicinal Chemistry

• 楊 永雄

  Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 吉崎 司郎

  (present Address)bio-center Nkk Corporation

• 吉崎 司郎

  Laboratories of Medicinal chemistry, Tokushima Factory, Otsuka Pharmaceutical Co., Ltd.

• 楊 永雄

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  Laboratories Of Medicinal Chemistry Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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• Syntheses and β-Adrenergic Blocking Activities of Carbostyril Derivatives
• Synthesis of 5,8-Dihydroxy-3,4-dihydrocarbostyril
• Synthesis and Pharmacological Evaluation of 7-Substituted Procaterol Derivatives
• Synthesis of Procaterol Derivative Having a Piperidylmethanol Group and Its β-Adrenoceptor Stimulant Activities
• Synthesis and Pharmacological Evaluation of Procaterol Derivatives Having a tert-Amino Group
• Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XII. : A New, Convenient Method for Synthesizing 3,5-Dihydroxy-6,7-dimethoxyflavones from 3,5,6,7-Tetramethoxyflavones
• Synthesis of 5-(2-Allylamino-1-hydroxyalkyl)-8-hydroxycarbostyrils, New β-Adrenoceptor Stimulants
• Synthesis of 8-Hydroxycarbostyril
• Synthesis of 5-(2-Amino-1-hydroxybutyl)-8-hydroxycarbostyril, One of the Major Metabolites of Procaterol
• Oxidation of Procaterol to 5-Formyl-8-hydroxycarbostyril
• Sympathomimetic Amines having a 3,4-Dihydrocarbostyril Nucleus
• Syntheses and β-Adrenergic Blocking Activities of the Optical Isomers of 8-Acetonyloxyl-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril

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