Synthesis of Procaterol Derivative Having a Piperidylmethanol Group and Its β-Adrenoceptor Stimulant Activities
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概要
- 論文の詳細を見る
A procaterol derivative (6) having a piperidylmethanol group was synthesized by the nucleophilic reaction of a 5-formylcarbostyril derivative with pyridyllithium, followed by selective catalytic reductions to afford the erythro-isomer. Compound 6 showed non-selective β-adrenoceptor agonist activities like those of l-isoproterenol in an in vivo assay using anesthetized dogs.
- 社団法人日本薬学会の論文
- 1989-12-25
著者
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玉田 重晴
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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薮内 洋一
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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吉崎 司郎
(present Address)bio-center Nkk Corporation
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梅里 正七男
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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吉崎 司郎
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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梅里 正七男
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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薮内 洋一
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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玉田 重晴
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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