Studies on Positive Inotropic Agents. V. : Synthesis of 1-Heteroaroylpiperazine Derivatives

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概要

• 論文の詳細を見る

• A series of 1-heteroaroylpiperazines (V-VII, XI) was synthesized and examined for positive inotropic activities on the canine heart. The key intermediates, heteroarenecarboxylic acids (III, X), were prepared by two different methods, and were condensed with substituted piperazines to give 1-heteroaroylpiperazines V-VII and XI. Among them, quinazoline derivatives (XI) were found to have potent positive inotropic activities.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 薮内 洋一

  大塚製薬徳島研究所

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 藤岡 孝文

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 小川 英則

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 玉田 重晴

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 寺本 修二

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 近藤 一見

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 山下 修司

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 富永 道明

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 藪内 洋一

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 藪内 洋一

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 近藤 一見

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 寺本 修二

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 山下 修司

  大塚製薬徳島研究所

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

• 小川 英則

  大塚製薬(株)徳島新薬第二研究所

• 玉田 重晴

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 藤岡 孝文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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