Studies on Antibacterial Agents. I. : Synthesis of Substituted 6,7-Dihydro-1-oxo-1H, 5H, -benzo{i, j]-quinolizine-2-carboxylic Acids

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概要

• 論文の詳細を見る

• A series of substituted 6,7-dihydro-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acids was synthesized and tested for antibacterial activities. Among them, 9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acid (OPC-7241) exhibited potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, and 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acid (OPC-7251) showed potent activity characteristically against Propionibacterium acnes.

• 社団法人日本薬学会の論文
• 1989-08-25

著者

• 上田 敬

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 石川 廣

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 宮本 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 田房 不二男

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 狩野 正信

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  大塚製薬株式会社微生物研究所

• 狩野 正信

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 宮本 寿

  大塚製薬株式会社微生物研究所

• 石川 廣

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

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