Synthesis and Antibacterial Activities of 2-Oxaisocephems
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概要
- 論文の詳細を見る
A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a 2-aminothiazol-4-yl moiety at the 7-position was synthesized via benzyl 3-acetyloxymethyl-7-azido-8-oxo-1-aza-4-oxabicyclo[4.2.0]oct-2-ene-2-carboxylate (2), derived from benzyl acetoacetate (1). The new 2-oxaisocephems were tested for antibacterial activities. Among them, the derivatives having a [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopentyloxyimino]acetamido group at the 7-position characteristically showed potent activities against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis as compared with cefuzonam and cefmenoxime, which are third-generation cephalosporins.
- 社団法人日本薬学会の論文
- 1994-10-15
著者
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辻 浩一
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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石川 廣
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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壺内 英継
Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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安村 貢一
Fujii, Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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Tsuji Kiyoshi
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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壺内 英継
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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Tsuji K
School Of Pharmaceutical Science University Of Shizuoka
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辻 京子
Faculty Of Pharmaceutical Sciences Setsunan University
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安村 貢一
Fujii Memorial Research Institute Otsuka Pharmaceutical Co. Ltd.
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