Study of the Pharmacological Effect of the Bile Salt, Sodium Scymnol Sulfate, from Rhizoprionodon acutus. II. : Prophylactic Effect of Scymnol on Lesion Development in a Rat Peripheral Arterial Occlusion Model
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概要
- 論文の詳細を見る
The effect of scymnol on the development of lesions in a rat peripheral arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated.In this model oral administration of scymnol significantly prevented edematous swelling and development of lower limb lesions, including gangrene, and also reduced changes in blood coagulation parameters, platelet aggregation and retention rate at a dose of 10 or 30 mg/kg. However, it had no effect on these clotting system functions in sham-operated rats at a dose of 10 mg/kg. The effects of scymnol were also compared with those of ticlopidine and argatroban.The findings suggest that scymnol may be clinically useful for preventing thrombotic peripheral arterial occlusive disorders. Its prophylactic action appears to be mainly due to its potent ability to protect against endothelial cell damage due to lactic acidosis.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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辻 浩一
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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Tsuji Kiyoshi
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nukaya Haruo
School of Pharmaceutical Sciences, University of Shizuoka
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ISHIDA HITOSHI
School of Pharmaceutical Science, University of Shizuoka
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NAKAYASU Hidetoshi
School of Pharmaceutical Science, University of Shizuoka
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Tsuji K
School Of Pharmaceutical Science University Of Shizuoka
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辻 京子
Faculty Of Pharmaceutical Sciences Setsunan University
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Nukaya H
School Of Pharmaceutical Science University Of Shizuoka
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Nukaya Haruo
School Of Pharmaceutical Science University Of Shizuoka
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TSUJI Kunirou
School of Pharmaceutical Science, University of Shizuoka
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Ishida Hitoshi
Research Institute For Bioresources Okayama University:(present Office)plant Protection Station Moji
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