Comparative Study on Reduction of Bone Loss and Lipid Metabolism Abnormality in Ovariectomized Rats by Soy Isoflavones, Daidzin, Genistin, and Glycitin

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概要

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• The effects of the soy isoflavone glycoside, daidzin, genistin, and glycitin on bone loss and lipid metabolism in ovariectomized(ovx) rats were compared with those of estrone. Thirty-six 11-week-old female Sprague-Dawley rats were assigned to six groups, sham-operated, ovx, ovx+glycitin, ovx+daidzin, ovxtgenistin, and ovx+estrone and fed matched amounts of a commercial calcium-deficient diet for 4 weeks. Throughout this period, daidzin, genistin or glycitin(25, 50 or 100 mg/kg/d) was given orally using a stomach tube, or estrone(7.5μg/kg/d) was administered subcutaneously. Daidzin, genistin and glycitin significantly prevented bone loss in ovx rats at a dose of 50mg/kg/d, like estrone. At this dose glycitin and daidzin also prevented ovx-induced uterine atrophy and increases in body weight gain, abdominal fat, serum total cholesterol and triglyceride, and urinary excretion of pyridinoline and deoxypyridinoline with statistical significance, like estrone. On the other hand, genistin prevented ovx-induced uterine atrophy only at a dose of 100 mg/kg, but did not block any other change of ovx rats at a dose of 50 or 100 mg/kg. These findings indicate that daidzin, glycitin, and genistin are effective in preventing bone loss and the former two compounds are effective in reversing the unfavorable changes of lipid metabolism in this model. It is suggested that the preventive effect of daidzin or glycitin on bone loss in ovx rats is due to suppression of bone turnover, as in the case of estrone, but genistin has a different mechanism of action from the other compounds. Soy isoflavone glycosides may represent a potential alternative therapy in the treatment of bone loss and lipid metabolism abnormality in ovarian hormone-deficient women.

• 公益社団法人日本薬学会の論文
• 2001-04-01

著者

• 辻 浩一

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

• TODA Toshiya

  Fujicco Co., Ltd.

• Ishida H

  School Of Pharmaceutical Science University Of Shizuoka

• Tsuji Kiyoshi

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• ISHIDA HITOSHI

  School of Pharmaceutical Science, University of Shizuoka

• TSUJI KUNIRO

  School of Pharmaceutical Science, University of Shizuoka

• UESUGI Takehiko

  Fujicco Ltd.

• Tsuji K

  School Of Pharmaceutical Science University Of Shizuoka

• 辻 京子

  Faculty Of Pharmaceutical Sciences Setsunan University

• Toda T

  Konan Univ. Kobe Jpn

• Toda Toshiya

  Fujicco Co. Ltd.

• Toda Tatsushi

  Division Of Functional Genomics Department Of Post-genomics And Diseases Osaka University Graduate S

• Ishida Hitoshi

  Research Institute For Bioresources Okayama University:(present Office)plant Protection Station Moji

• Uesugi T

  Fujicco Co. Ltd. Kobe Jpn

• Uesugi Takehiko

  Research & Development Laboratory Fujicco Co. Ltd.

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