Study on the Bile Salt from Megamouth Shark. I. The Structures of a New Bile Alcohol, 7-Deoxyscymnol, and Its New Sodium Sulfates

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概要

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• New sodium bile alcohol sulfates were obtained from the bile of megamouth shark by chromatography on silica gel and Sephadex LH-20,together with two sodium scymnol sulfates, (24R, 25S)- and (24R, 25R)-(+)-3α, 7α, 12α, 26-pentahydroxy-5β-cholestan-27-yl sodium sulfate (2 and 3). On hydrolysis in pyridine-dioxane, the new salts afforded a new bile alcohol (1), whose structure was determined to be (24R)-5β-cholestane-3α, 12α, 24,26,27-pentol, besed on chemical and spectral data. On the basis of the physicochemical data, the new salts were established as (24R, 25S)- and (24R, 25R)-(+)-3α, 12α, 24,26-tetrahydroxy-5β-cholestan-27-yl sodium sulfate.

• 公益社団法人日本薬学会の論文
• 1996-07-15

著者

• 辻 浩一

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

• Ishida H

  School Of Pharmaceutical Science University Of Shizuoka

• Tsuji Kiyoshi

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Miyamoto H

  Osaka Univ. Osaka

• Nukaya Haruo

  School of Pharmaceutical Sciences, University of Shizuoka

• ISHIDA HITOSHI

  School of Pharmaceutical Science, University of Shizuoka

• TSUJI KUNIRO

  School of Pharmaceutical Science, University of Shizuoka

• NAKAYASU Hidetoshi

  School of Pharmaceutical Science, University of Shizuoka

• MIYAMOTO Hidekazu

  School of Pharmaceutical Science, University of Shizuoka

• KAJINO Takako

  School of Pharmaceutical Science, University of Shizuoka

• Tsuji K

  School Of Pharmaceutical Science University Of Shizuoka

• 辻 京子

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nukaya H

  School Of Pharmaceutical Science University Of Shizuoka

• Nukaya Haruo

  School Of Pharmaceutical Science University Of Shizuoka

• Kajino Takako

  School Of Pharmaceutical Science University Of Shizuoka

• Miyamoto H

  Department Of Research And Development Nicca Chemical Co. Ltd.

• Ishida Hitoshi

  Research Institute For Bioresources Okayama University:(present Office)plant Protection Station Moji

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