Therapeutic Effect of Cytomedicine on Mesangio-Proliferative Glomerulonephritis in Human Interleukin-6 Transgenic Mice
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概要
- 論文の詳細を見る
We previously demonstrated that IgG1 plasmacytosis in human interleukin-6 transgenic mice (hIL-6 Tgm) was suppressed by the implantation of SK2 hybridoma cells (SK2 cells, which secrete anti-hIL-6 monoclonal antibodies) microencapsulated in a semipermeable and biocompatible device. In this study, we demonstrated that the mesangioproliferative glomerulonephritis in hIL-6 Tgm was also improved by the same treatment. These results strongly support the concept of cytomedicine, which is a novel drug delivery system (DDS) using living cells. However, an electron microscopy study showed that cytomedicine has a limited duration of effectiveness because of the disappearance of space for cell proliferation in the microcapsule. Thus, the control of cell proliferation in a device must be developed to prolong the function and effectiveness of cytomedicine.
- 社団法人日本薬学会の論文
- 1997-03-15
著者
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
Faculty Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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MIYAMOTO Hajime
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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YOSHIOKA Tatsunobu
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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KATSUME Asao
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.
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SAITO Hiroyuki
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.
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OHSUGI Yoshiyuki
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.,
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MAYUMI Tadanori
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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OKADA Naoki
Faculty of Graduate School of Pharmaceutical Sciences, Osaka University
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YOROZU Keigo
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.
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UEDA Otoya
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.
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Katsume A
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.
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Miyamoto H
Osaka Univ. Osaka
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Okada N
Graduate School Of Pharmaceutical Sciences Osaka University
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UEDA Otoya
Laboratory of Molecular Genetics and Embryology, CSK Research Park Inc.
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Yoshie Osamu
Department Of Cancer Research Fuji Gotemba Research Laboratories Chugai And Pharmaceutical Co
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Ohsugi Yoshiyuki
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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Miyamoto H
Department Of Research And Development Nicca Chemical Co. Ltd.
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Ueda Otoya
Laboratory Of Molecular Genetics And Embryology Csk Research Park Inc.
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Ueda O
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.
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Yorozu Keigo
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.
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Yoshikawa Tomoaki
Department Of Toxicology And Safety Science Graduate School Of Pharmaceutical Sciences Osaka Univers
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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