Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity
スポンサーリンク
概要
- 論文の詳細を見る
Oral administration of carnosine (β-alanyl-L-histidine) in mice treated with restraint stress moderately alleviated a stress-induced decrease in plasma oxygen radical absorbance capacity (ORAC) activity (P = 0.075). Carnosine treatment also increased the level of plasma glutathione (GSH) and ascorbic acid compared with those in the restraint stress mice. Carnosine and related compounds anserine, histidine and histamine exhibited ORAC activity in vitro, while β-alanine was not effective. These results suggest that carnosine exerts a protective effect against the stress-induced elevation of the oxidative level in plasma.
- 2009-03-01
著者
-
Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
-
Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
-
深見 治一
Institute For Biomedical Research Research Center Suntory Ltd.
-
深見 治一
サントリー(株)基礎研
-
Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Tsuruoka N
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Tsuruoka Nobuo
Laboratory Of Cell Biology Institute For Biomedical Research Suntory Limited Research Center
-
ABE Keiich
BRAND’S Centre for Health and Nutritional Sciences
-
KURIHARA Hiroshi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
-
Nagai Hajime
Brand's Centre For Health And Nutritional Sciences
-
Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
-
Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
-
FUKAMI Harukazu
Department of Bioscience and Biotechnology, Faculty of Bioenvironmental Science, Kyotogakuen Univers
-
Kawanishi Hideaki
Institute For Health Care Science Suntory Ltd.
-
Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Abe Keiich
Brand's Centre For Health And Nutritional Sciences
-
Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
-
Fukami Harukazu
Dep. Of Bioscience And Biotechnology Fac. Of Bioenvironmental Sci. Kyotogakuen Univ.
-
Fukami Harukazu
Institute For Health Care Science Technological Development Center Suntory Ltd.
-
Kurihara H
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
-
Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
-
Tsuruoka Nobuo
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
-
Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
-
Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
-
Shibata Hiroshi
Institute Of Health Care Science Suntory Wellness Limited
関連論文
- Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain(Biochemistry)
- 新規ジフェニルエーテル系化合物の Protoporphyrinogen-IX Oxidase 阻害
- Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF : Useful Information for Designing Artificial Proteo-Antagonists
- Creation of Novel Protein Transduction Domain (PTD) Mutants by a Phage Display-Based High-Throughput Screening System(Biochemistry)
- Quality Enhancement of the Non-immune Phage scFv Library to Isolate Effective Antibodies(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Immunoglobulin E antibody production against house dust mite, Dermatophagoides farinae, in mice.
- A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C : a multicenter, prospective, randomized, controlled trial in Japan
- A129 新規ジフェニルエーテル誘導体の合成と除草活性
- Development of new anti-TNF therapy
- Development of Novel Drug Delivery System (DDS) Technologies for Proteomic-Based Drug Development
- Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy (Pharmacognosy)
- Effective Cancer Targeting Using an Anti-tumor Tissue Vascular Endotheliumm specific Monoclonal Antibody (TES-23)
- Prolongation of the Effective Duration of Cytomedical Therapy by Re-injecting SK2 Hybridoma Cells Microencapsulated within Alginate-Poly(L)lysine-Alginate Membranes into Human Interleukin-6 Transgenic Mice
- Therapeutic Effect of Cytomedicine on Mesangio-Proliferative Glomerulonephritis in Human Interleukin-6 Transgenic Mice
- 4. 合成法(MAIN TOPIC 1 CHEMISTRY AND BIOACTIVITY OF NEW SYNTHETIC COMPOUNDS)(第 7 回国際農薬化学会議)
- 2. 殺菌剤(MAIN TOPIC 1 CHEMISTRY AND BIOACTIVITY OF NEW SYNTHETIC COMPOUNDS)(第 7 回国際農薬化学会議)
- Purification and Characterization of a Novel Vascular Endothelial Cell Growth Inhibitor Secreted by Macrophage-Like U-937 Cells
- Effects of a Chicken Extract on Food-Deprived Activity Stress in Rats
- Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress
- The Anti-stress Effects of Sarcandra glabra Extract on Restraint-Evoked Immunocompromise(Pharmacology)
- Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46
- Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity
- Protective Effects of Radix Rosa laevigata against Propionibacterium acnes and Lipopolysaccharide-Induced Liver Injury
- Effects of Oolong Tea on Plasma Antioxidative Capacity in Mice Loaded with Restraint Stress Assessed Using the Oxygen Radical Absorbance Capacity (ORAC) Assay(Pharmacognosy)
- Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus Strains Isolated Clinically(Miscellaneous)
- Identification of the Up- and Down-Regulated Genes in the Heart of Juvenile Visceral Steatosis Mice (Biochemistry/Molecular Biology)
- Functional Disorders of the Oxidative Phosphorylation System in the Heart Mitochondria of Mice with Juvenile Visceral Steatosis
- Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses
- Synaptic plasticity preserved with arachidonic acid diet in aged rats
- Effect of Anti-IL-5 Monoclonal Antibody on Allergic Bronchial Eosinophilia and Airway Hyperresponsiveness in Mice.
- Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
- Effect of Cocoa Tea (Camellia ptilophylla) Co-Administrated with Green Tea on Ambulatory Behaviors
- Fortuneanosides G-L, Dibenzofuran Glycosides from the Fruit of Pyracantha fortuneana
- Priming with Murine Recombinant Interleukin-5 Resulted in the Augmentation of PAF-Induced Airway Hyperresponsiveness to Histamine in Guinea Pigs.
- Effect of Murine Recombinant Interleukin-5 on Bronchial Reactivity in Guinea-Pigs.
- The mechanism supplying acetyl-CoA for terpene biosynthesis in sweet potato with black rot: Incorporation of acetate-2-^C, pyruvate-3-^C and citrate-2,4-^C into ipomeamarone
- Oxidation of Arachidonoyl Glycerols Encapsulated with Saccharides
- Possible Role of Mitochondrial Remodelling on Cellular Triacylglycerol Accumulation
- Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
- Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice
- Dynamics of Mitochondria during the Cell Cycle(Molecular and Cell Biology)
- Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
- Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
- The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
- Anti-Stress Effect of Oolong Tea in Women Loaded with Vigil
- Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide(Pharmacology)
- Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
- Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
- Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
- Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
- Preventive Effect of a Chicken Extract on the Development of Hypertension in Stroke-prone Spontaneously Hypertensive Rats(Food & Nutrition Science)
- Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
- Synthesis and Herbicidal Activity of Pyridinyloxyphenoxypropionamides
- Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
- Enlarging splenic vein aneurysm associated with increasing portal hypertension
- PI3-kinase p85α Is a Target Molecule of Proline-rich Antimicrobial Peptide to Suppress Proliferation of ras-Transformed Cells
- Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
- Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
- Synthesis of Novel Succinamide Derivatives Having the 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. I
- New Selective Grass Herbicides and Their Hydrolytic Properties as Pro-herbicides
- Specific Suppression of Antigen-Angibody Reactions by a Dialysate from Dermatophagoides farinae.
- SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
- IMMUNOGLOBULIN E ANTIBODY PRODUCTION AGAINST HOUSE DUST MITE, DERMATOPHAGOIDES FRARINAE, IN MICE
- Effects of Oolong Tea on Metabolism of Plasma Fat in Mice under Restraint Stress(Food & Nutrition Science)
- Effect of Murine Recombinant Interleukin-5 on the Cell Population in Guinea-Pig Airways.
- A Novel Vitamin C Analog, 2-O-(β-D-Glucopyranosyl) Ascorbic Acid : Examination of Enzymatic Synthesis and Biological Activity(Brewing and Food Technology)
- First Chemical Synthesis of Antioxidative Metabolites of Sesamin
- Comparison of the Immunomodulatory Effects of Live and Heat-killed Lactobacillus pentosus S-PT84
- Pharmacology in Health Foods:Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- Effect of Dietary Enrichment with n-3 Polyunsaturated Fatty Acids (PUFA) or n-9 PUFA on Arachidonate Metabolism in Vivo and Experimentally Induced Inflammation in Mice (Biochemistry/Molecular Biology)
- Clinical Study on the Combined Effect of Capsaicin, Green Tea Extract and Essence of Chicken on Body Fat Content in Human Subjects
- Effects of Chicken Essence Tablets on Resting Metabolic Rate(Food & Nutrition Science)
- Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin
- Inhibitory Mechanism of Mizoribine on the Antibody Production of Mouse B Cells Stimulated with Lipopolysaccharide
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- Effects of the Antlered Form of Ganoderma lucidum on Tumor Growth and Metastasis in Cyclophosphamide-Treated Mice
- Hypoglycemic Action of Cyclocarya paliurus (Batal.) Iljinskaja in Normal and Diabetic Mice(Food & Nutrition Science)
- Hypolipcmic Effect of Cyclocarya paliurus (Batal) Iljinskaja in Lipid-Loaded Mice
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Protective Effects of Radix Rosa laevigata against Propionibacterium acnes and Lipopolysaccharide-Induced Liver Injury
- The Anti-stress Effects of Guangdong Herbal Tea on Immunocompromise in Mice Loaded with Restraint Stress
- Chemical Synthesis of Astaxanthin n-Octanoic Acid Monoester and Diester and Evaluation of Their Oral Absorbability
- Synthesis and Biological Evaluation of Phenylacetyl Derivatives Having Low Central Nervous System Permeability as Potent and Selective M_2 Muscarinic Receptor Antagonists
- Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. II
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- Enzymatic Synthesis of Astaxanthin n-Octanoic Acid Esters
- Role of cell surface H^+-ATP synthase on adipocyte differentiation
- Effect of Cocoa Tea (Camellia ptilophylla) Co-Administrated with Green Tea on Ambulatory Behaviors
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- The Hypoglycemic Effects of Camellia assamica var. kucha Extract
- Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
- Effects of a Purified Saponin Mixture from Alfalfa on Plasma Lipid Metabolism in Hyperlipidemic Mice
- Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice
- Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
- Pharmacology in Health Foods : Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet
- Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice
- Identification of the Metabolites of Episesamin in Rat Bile and Human Liver Microsomes
- Effects of Heat-Killed Lactobacillus pentosus S-PT84 on Postprandial Hypertriacylglycerolemia in Rats