Chemical Synthesis of Astaxanthin n-Octanoic Acid Monoester and Diester and Evaluation of Their Oral Absorbability
スポンサーリンク
概要
- 論文の詳細を見る
We chemically synthesized astaxanthin n-octanoic acid monoester and diester from free astaxanthin and n-octanoic acid by a dehydration reagent in 32 and 22% yield, respectively. The oral absorbability of the n-octanoic acid monoester and diester was evaluated by examining the plasma and liver concentrations of astaxanthin after oral administration of the compounds. The monoester significantly increased the plasma and liver concentration of astaxanthin compared with the long-chain fatty acid ester mixture derived from Haematococcus algae. The diester is inclined to increase it although it is not significant. It is possible that medium-chain fatty acid esters give better oral-absorbability of astaxanthin than long-chain fatty acid esters.
- 日本油化学会の論文
著者
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深見 治一
サントリー(株)基礎研
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NAKAO Masahiro
Institute for Biomedical Research, Suntory Ltd.
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FUKAMI Harukazu
Department of Bioscience and Biotechnology, Faculty of Bioenvironmental Science, Kyotogakuen Univers
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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Fukami Harukazu
Dep. Of Bioscience And Biotechnology Fac. Of Bioenvironmental Sci. Kyotogakuen Univ.
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Fukami Harukazu
Institute For Health Care Science Technological Development Center Suntory Ltd.
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Nakao Masahiro
Institute For Biomedical Research Suntory Ltd.
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NAMIKAWA Koshi
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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SUGIURA-TOMIMORI Namino
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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SUMIDA Motoo
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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KATANO Kenji
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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NAKAO Masahiro
Institute for Advanced Technology, Technological Development Center, Suntory Ltd.
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