Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
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概要
- 論文の詳細を見る
In the present study, we investigated the anti-oxidant activity of oolong tea in an oxidation model using human low-density lipoprotein (LDL). Oolong tea suppressed the oxidation of LDL induced by 2-2'-azobis 4-methoxy-2,4-dimethyvaleronitrile (V70) in a dose-dependent manner, that is, it prolonged the lag time to 114.3%, 138% and 199.9% as compared with the control group at 0.5μg/ml, 1.0μg/ml, and 2.5μg/ml, respectively. We also determined the scavenging effect of oolong tea on active oxygen radicals using the electron spin resonance (ESR) technique with 5,5-dimethy1-1-pyrroline N-oxide (DMPO) as a spin trapping agent. The intensity of the ESR signals for the DMPO-OOH adduct formed by the hypoxanthine/xanthine oxidase reaction system with DMPO decreased in the presence of oolong tea. The IC_<50> of oolong tea was 19.9μg/ml. These findings suggested that oolong tea has beneficial effects on health related to its anti-oxidative action.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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SHIBATA Hiroshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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深見 治一
Institute For Biomedical Research Research Center Suntory Ltd.
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深見 治一
サントリー(株)基礎研
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Tsuruoka N
Laboratory For Health Care Science Research Center Suntory Ltd.
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KURIHARA Hiroshi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka Takaharu
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kawanishi Hideaki
Institute For Health Care Science Suntory Ltd.
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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Tsuruoka Nobuo
Institute for Health Care Science, Research Center, Suntory Ltd.
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Fukami Harukazu
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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TOYODA Yoshiko
Institute for Health Care Science, Suntory Ltd.
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Toyoda Yoshiko
Institute For Health Care Science Suntory Ltd.
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KAGEYAMA Norihiko
Institute far Health Care Science, Suntory Ltd.
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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Fukami Harukazu
Dep. Of Bioscience And Biotechnology Fac. Of Bioenvironmental Sci. Kyotogakuen Univ.
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Fukami Harukazu
Institute For Health Care Science Technological Development Center Suntory Ltd.
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Kageyama Norihiko
Institute Far Health Care Science Suntory Ltd.
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Kurihara H
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
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Tsuruoka Nobuo
Institute For Health Care Science Suntory Limited
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Tanaka Takaharu
Institute For Fundamental Research Suntory Ltd.
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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Tanaka Takaharu
Institute For Biomedical Research Suntory Ltd.
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Shibata Hiroshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.:department Of Animal Scienc
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SHIBATA Hiroshi
Institute for Biomedical Research, Suntory Limited
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