Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
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概要
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In the present study, we evaluated the relationship between the antihypertensive effect of sesamin, a lignan from sesame oil, and its antioxidative activity in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. After a 5-week treatment period, systolic blood pressure was significantly elevated in normal diet-fed DOCA-salt animals compared with cases in sham-operated animals. Sesamin feeding, tempol (a superoxide dismutase mimetic) treatment or antihypertensive drugs combination (triple therapy; reserpine, hydralazine, hydrochlorothiazide) significantly suppressed the development of DOCA-salt-induced hypertension. Compared with sham-operated rats, the normal diet-fed DOCA-salt rats revealed marked increases in aortic superoxide (O_2^-) production. These increases in O_2^- production were significantly suppressed by sesamin feeding or tempol treatment, but not by triple therapy. Acetylcholine (Ach)-induced endothelium-dependent relaxation was markedly decreased in normal diet-fed DOCA-salt rats, compared with cases in sham-operated rats. Sesamin feeding and triple therapy significantly improved the DOCA-salt-induced impairment of endothelium-dependent relaxation. However, tempol treatment had no effect on the impaired vasodilator responses induced by DOCA-salt treatment. In DOCA-salt rats with or without sesamin feeding, systolic blood pressure significantly correlated with both aortic O_2^- production and endothelium-dependent vascular relaxation. These findings suggest that sesamin feeding inhibits the enhancement of aortic O_2^- production in DOCA-salt hypertensive rats, and this effect may contribute to the antihypertensive effect of sesamin. Sesamin feeding-induced improvement of endothelial dysfunction seems to result from the above antioxidative and antihypertensive effects.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Tsuruoka N
Laboratory For Health Care Science Research Center Suntory Ltd.
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Nakano Daisuke
Osaka University of Pharmaceutical Sciences Osaka Medical College
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NAKANO Daisuke
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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ISHII Fumie
Department of Pharmacology, Osaka University of Phiarmaceutical Sciences
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka Takaharu
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Kawanishi Hideaki
Institute For Health Care Science Suntory Ltd.
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Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Tsuruoka Nobuo
Institute for Health Care Science, Research Center, Suntory Ltd.
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KAWANISHI Hideaki
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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Kawashima H
Institute For Health Care Science Research Center Suntory Ltd.
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Ishii F
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Nakano Daisuke
Osaka University Of Pharmaceutical Sciences
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Nakano Daisuke
Department Of Organic Chemistry Graduate School Of Pharmaceutical Sciences Tohoku University
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ITOH Chie
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kawashima Hideaki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Kurihara H
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
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Tsuruoka Nobuo
Institute For Health Care Science Suntory Limited
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Tanaka Takaharu
Institute For Fundamental Research Suntory Ltd.
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Itoh C
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Itoh Chie
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Fukuoka University
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Tanaka Takaharu
Institute For Biomedical Research Suntory Ltd.
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Kawanishi Hideaki
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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