Exaggerated Renal Pathology of Partial Ablation-Induced Chronic Renal Failure in eNOS Deficient Mice(Pharmacology)
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概要
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We investigated the role of endothelial nitric oxide synthase (eNOS) in the remnant kidney model of chronic renal failure, by using eNOS-deficient (eNOS^<-/->) and wild-type mice. There were significant increments of blood urea nitrogen level, plasma creatinine concentration and proteinuria in both wild-type and eNOS^<-/-> mice at 8 weeks after 5/6 nephrectomy, but observed changes were more prominent in eNOS^<-/-> mice. Only 7 out of 30 eNOS^<-/-> mice were alive during 8-week experimental period, whereas survival rate in the wild-type mice was 69%. The glomerular size distribution indicated that the glomeruli of 5/6 nephrectomized eNOS^<-/-> mice tended to be larger compared with cases of wild-type mice. It seems likely that eNOS-derived NO is protective against renal injuries in this disease model.
- 2008-05-01
著者
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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YAMASHITA Chika
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Ohkita Mamoru
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Yamashita Chika
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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Tazawa Naoko
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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