Protective Effect of KB-R7943, a Novel Na^+/Ca^<2+> Exchange Inhibitor, on Ischemic Acute Renal Failure in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate), a novel Na+/Ca2+ exchange inhibitor, on ischemic acute renal failure (ARF) in rats were examined. ARF was induced by clamping the left renal pedicle for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function was markedly diminished in ARF rats. Pretreatment with KB-R7943 (10 mg/kg, i.v.) markedly attenuated the ARF-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, which was suppressed by KB-R7943. Activation of the reverse mode of Na+/Ca2+ exchange seems to play an important role in the pathogenesis of ARF. A selective Na+/Ca2+ exchange inhibitor may be useful in cases of ARF.
- 社団法人 日本薬理学会の論文
著者
-
Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
-
MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
-
KOBAYASHI YUTAKA
Department of Pediatrics, Kobe Central Municipal Hospital
-
Kobayashi Yutaka
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
-
Kobayashi Masayuki
Hematology Division National Cancer Center Hospital
-
Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
-
Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
-
Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
-
Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
-
Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
-
KURO Toshihiko
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
-
Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
-
Kawai Yu
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
-
Kuro T
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
-
Kuro Toshihiko
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
-
Kobayashi Yutaka
Department Of Cardiovascular Surgery Iwaki Kyoritsu General Hospital
-
Kobayashi Yutaka
Department Of Applied Physics Fukui University
関連論文
- Drug Discovery for Overcoming Chronic Kidney Disease (CKD) : The Endothelin ET_B Receptor / Nitric Oxide System Functions as a Protective Factor in CKD
- Histological and immunophenotypic changes in 59 cases of B-cell non-Hodgkin's lymphoma after rituximab therapy
- Progressive multifocal leukoencephalopathy in a patient with B-cell lymphoma during rituximab-containing chemotherapy : case report and review of the literature
- Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma
- Diffuse large B-cell lymphoma after transformation from low-grade follicular lymphoma : morphological, immunohistochemical, and FISH analyses
- Nocardia exalbida brain abscess in a patient with follicular lymphoma
- Phase I and II pharmacokinetic and pharmacodynamic study of the proteasome inhibitor bortezomib in Japanese patients with relapsed or refractory multiple myeloma
- A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL
- Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice
- Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma
- Phase I study of radioimmunotherapy with an anti-CD20 murine radioimmunoconjugate (^Y-ibritumomab tiuxetan) in relapsed or refractory indolent B-cell lymphoma
- Durable Response but Prolonged Cytopenia after Cladribine Treatment in Relapsed Patients with Indolent non-Hodgkin's Lymphomas : Results of a Japanese Phase II Study
- t(11 ; 18)-Bearing Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Responding to Cladribine
- Two Entities of Precursor T-Cell Lymphoblastic Leukemia/Lymphoma Based on Radiologic and Immunophenotypic Findings
- Antihypertensive Effect of Sesamin. III. Protection against Development and Maintenance of Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
- PHARMACOKINETICS AND CLINICAL EFFECTS OF CEFOZOPRAN IN PEDIATRIC PATIENTS
- OJ-062 Effect of Chymase Inhibition by NK-3201 on Hypoxia-Induced Left Ventricular Remodeling in Mice(Cardiovascular pharmacology, basic/clinical(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- EFFECTS OF PINACIDIL ON RENAL HEMODYNAMICS AND FUNCTION IN ANESTHETIZED DOGS
- EFFECTS OF TINORIDINE ON LIPID PEROXIDATION AND RENIN RELEASE IN THE RAT RENIN GRANULE FRACTION
- EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS ON RENIN RELEASE FROM RAT KIDNEY CORTICAL SLICES
- Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia(Experimental Investigation)
- OE-012 Angiotensin II Receptor Blocker Inhibits NF-κ B Activity and Prevents Hypoxia-Induced Fibrosis of Left Ventricular Myocardium in Apolipoprotein E-Knockout Mice(Chronic coronary heart disease/Remodeling-1 (IHD) OE2,Oral Presentation (English),The 70
- Chronic Hypoxia Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Knockout Mice
- Nifedipine Enhances the Cardioprotective Effect of an Angiotensin-II Receptor Blocker in an Experimental Animal Model of Heart Failure
- Mechanisms of Combined Treatment With Celiprolol and Candesartan for Ventricular Remodeling in Experimental Heart Failure
- Ghrelin Improved Diastolic Dysfunction Induced by Hypoxia in Diabetic OLETF Rats(Heart Failure, Basic 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Nifedipine Decreases Oxidative Stress and Exhibits Cardiovascular Protection in Diabetic Rats Exposed to Hypoxia(Diabetes/Obesity 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-322 Hypoxia Induces Atherogenesis of Apolipoprotein E-knockout Mice through Superoxide Production(Atherosclerosis, Basic 5 (IHD) : PE55)(Poster Session (English))
- OE-320 Angiotensin-II Receptor Blocker Exhibits Cardioprotection through Modulation of Cytokine Expression in the Metabolic Syndrome Accompanied with Hypoxia(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- Nifedipine Enhances Cardioprotective Effect of Angiotensin-II Receptor Blocker in Progressive Heart Failure
- Endothelin ETA Receptor Antagonist Suppressed ET-1 Content and INOS but Could Not Improve the Cardiac Dysfunction in Dilated Cardiomyopathy
- Short-Term Treatment at Vascular Injury with a Free Radical Scavenger Effectively Blunted Vascular Injury Response in Diabetic Rats
- New Concept of Cardioprotection in Diabetes Mellitus from a Viewpoint of Intracellular Free-Thiol Stabilization by Ebselen
- PJ-312 Intermittent Hypoxia Accelerates Cardiovascular Remodeling due to Postprandial Hyperglycemia in Lean Mice(PJ053,Metabolic Syndrome 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-425 Left Ventricular Remodeling Induced by Intermittent Hypoxia : Role of gp91phox Subunit of NADPH Oxidase(Heart failure, basic(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-398 Nuclear Factor-κ B Activation Accelerates Cardiac Hypertrophy, Interstitial Fibrosis, and Oxidative Stress in Diabetic Rats Exposed to Intermittent Hypoxia(Chronic coronary heart disease/Remodeling-2, The 71st Annual Scientific Meeting of the Japan
- Angiotensin II Receptor Blocker Reduces Oxidative Stress and Attenuates Hypoxia-Induced Left Ventricular Remodeling in Apolipoprotein E-Knockout Mice
- Ovariectomized Female Rats Showed More Favorable Response to Statin-therapy for Vasoprotection than Male Rats against Vascular Injury(Atherosclerosis, Basic 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Selective Endothelin ET_B Receptor Antagonist Improves Left Ventricular Function but Exaggerates Degeneration of Cardiomyocytes in J2N-k Hamsters
- Angiotensin-II receptor antagonist combined with β-adrenergic blocker improves left ventricular systolic and diastolic dysfunction in advanced heart failure
- Staphylococcal scalded skin syndrome in a uremic patient undergoing maintenance hemodialysis
- Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses
- Crescentic glomerulonephritis with antimyeloperoxidase antibodies developing during the course of IgA nephropathy in a patient with rheumatoid arthritis
- ^F-Fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of idiopathic retroperitoneal fibrosis associated with mediastinal fibrosis
- STIMULANT EFFECTS OF W-7,A CALMODULIN-ANTAGONIST, ON RENIN RELEASE FROM RAT KIDNEY CORTICAL SLICES
- EFFECTS OF VITAMIN E DEPLETION AND REPLETION ON RENIN RELEASE FROM RENIN GRANULES
- EFFECT OF VITAMIN E-DEFICIENCY ON RENIN RELEASE FROM RENIN GRANULES
- Selective Antagonism of the ET_A Receptor, but Not the ET_B Receptor, Is Protective Against Ischemic Acute Renal Failure in Rats
- Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
- Studies of Elastic Waves in Ethylene Propylene Rubber Using Acoustic Emission Sensor
- Injury to the Tricuspid Valve and Membranous Atrioventricular Septum Caused by Huge Calcified Right Ventricular Myxoma : Report of a Case
- Xanthoangelol D Isolated from the Roots of Angelica keiskei Inhibits Endothelin-1 Production through the Suppression of Nuclear Factor-κB(Pharmacology)
- Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
- Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
- Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
- Preventive Effect of a Chicken Extract on the Development of Hypertension in Stroke-prone Spontaneously Hypertensive Rats(Food & Nutrition Science)
- Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
- A CASE OF RENAL TRANSPLANT RECIPIENT COMPLICATED WITH CRYPTOCOCCOSIS AND AMPHOTERICIN B INDUCED ACUTE TUBULAR NECROSIS
- Deflection-Flipping Waves in a Symmetric Channel with Spatially Periodic Expansions and Contractions(Electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid mechanics)
- Development of a pulsatile flow-generating circulatory-assist device
- Mutual separation of hinge-glycopeptide isomers bearing five N-acetylgalactosamine residues from normal human serum immunoglobulin A1 by capillary electrophoresis
- Aggregated human serum immunoglobulin A1 induced by neuraminidase treatment had a lower number of O-linked sugar chains on the hinge portion
- Application of matrix-assisted laser desorption ionization time-of-flight mass spectrometry to the analysis of glycopeptide-containing multiple O-linked oligosaccharides
- Estimation of the Number of O-Linked Oligosaccharides per Heavy Chain of Human Serum IgAl by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOFMS) Analysis of the Hinge Glycopeptide
- Endothelin ET_B Receptor-Mediated Action on Systemic and Renal Hemodynamics and Urine Formation in Deoxycorticosterone Acetate-Salt-Induced Hypertensive Rats
- Cathodoluminescence scanning electron microscopy observations of (SrBaCa)TiO_3 ceramic varistors
- Electron Captute Cross Sections of H(2p) Level in the Intermadiate Velocity Regime of H^+_-Na(3s),Na(3p) Collisions
- Behaviors of Excitation Cross Sections in the Intermediate Velocity Regime on Ion-Atom Collisions
- Some Characteristics of Exact Strained Solutions to the Two Dimensional Navier-Stokes Equations
- Selective Antagonism of Endothelin ET_A or ET_B Receptor in Renal Hemodynamics and Function of Deoxycorticosterone Acetate-Salt-Induced Hypertensive Rats
- Effects of Pre- and Post-ischemic Treatments with FK409, a Nitric Oxide Donor, on Ischemia/Reperfusion-Induced Renal Injury and Endothelin-1 Production in Rats(Pharmacology)
- Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
- P7-16 Role of nitric oxide in the development and progression of ischemic acute renal failure in rats(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st An
- Role of Endogenous Angiotensin II in Renal Hemodynamic and Excretory Responses to L-Arginine Infusion
- RENIN RELEASE AND LIPID PEROXIDATION BY ASCORBIC ACID IN THE RENIN GRANULE FRACTION OF RAT KIDNEY CORTEX
- Sex Difference in Ischemic Acute Renal Failure in Rats : Approach by Proteomic Analysis(Pharmacology)
- Effects of the Endothelin ET_A-Receptor Antagonist FR139317 on Development of Hypertension and Cardiovascluar Hypertrophy in Deoxycorticosterone Acetate-Salt Hypertensive Rats
- Tempol Protects against Ischemic Acute Renal Failure by Inhibiting Renal Noradrenaline Overflow and Endothelin-1 Overproduction(Pharmacology)
- A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells
- Involvement of Proteasome in Endothelin-1 Production in Cultured Vascular Endothelial Cells
- Protective Effect of SM-19712, a Novel and Potent Endothelin Converting Enzyme Inhibitor, on Ischemic Acute Renal Failure in Rats
- Protective Effect of KB-R7943, a Novel Na^+/Ca^ Exchange Inhibitor, on Ischemic Acute Renal Failure in Rats
- Chaotic Motions in an Oscillatory Soliton Lattice
- Bortezomib plus dexamethasone for relapsed or treatment refractory multiple myeloma : the collaborative study at six institutes in Kyoto and Osaka
- Effect of Sodium Intake on Urinary Renin Excretion in Rats
- RENAL INACTIVE KALLIKREIN AS THE POSSIBLE ORIGIN OF URINARY INACTIVE KALLIKREIN IN THE RAT
- CONVERSION OF LOW MOLECULAR WEIGHT RENIN INTO THE HIGH MOLECULAR WEIGHT FORM BY Cu^ IN THE RAT KIDNEY
- Carcinoembryonic Antigen Positive Adenocarcinoma of a Female Urethral Diverticulum: Case Report and Review of the Literature
- Pathogenetic Significance of Myxomatous Degeneration in Fenestration-Related Massive Aortic Regurgitation
- Echocardiographic and Surgical Findings of Spontaneous Avulsion of the Aortic Valve Commissure
- Si MIS Solar Cells by Anodization
- Monte Carlo Simulation for Ising Spins on the Corner-Sharing Tetrahedron Lattices
- Homozygous Deletion of the Atrial Natriuretic Peptide Gene Exaggerated Cardiac Enlargement in Response to Volume Overload in Mice
- Serum calcitonin gene-related peptide levels in untreated prostate cancer patients
- Roles of Vasopressin and Hypertonicity in Basolateral Na/K/2Cl Cotransporter Expression in Rat Kidney Inner Medullary Collecting Duct Cells
- Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts
- Effects of Acarbose on the Acceleration of Postprandial Hyperglycemia-Induced Pathological Changes Induced by Intermittent Hypoxia in Lean Mice
- Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats
- Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan
- Effects of CV-4093, a new dihydropyridine calcium channel blocker, on renal hemodynamics and function in strke-prone spontaneously hypertensive rats(SHRSP).