Effect of Sodium Intake on Urinary Renin Excretion in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study was carried out to investigate the effect of sodium intake on urinary renin excretion in rats. Renin activity was measured before and after acidification, by radioimmunoassay of angiotensin I generated by incubation with partially purified homologous renin substrate. The molecular weight of renin was determined by gel filtration. Low sodium intake for 4 weeks resulted in a 16-fold increase in urinary renin excretion and led to a 15-fold increase in plasma renin activity. A 2.5-fold increase in renal renin content was simultaneously observed. In contrast, high sodium intake for 4 weeks decreased urinary renin excretion, plasma renin activity and renal renin content to about 20%, 25% and 35% of the control level, respectively. No significant change in renin activity after acidification was observed in all the urine samples. The molecular weight of renin in the urine from rats on low or high sodium intake was 40000,the value being identical with that from control rats. These results indicate that urinary renin excretion is well correlated with plasma renin activity, and that only active renin with a molecular weight of 40000 is excreted in the urine of rats, even under conditions of altered sodium intake.
- 公益社団法人日本薬学会の論文
著者
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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Iwamoto Takahiro
Department of Pharmacology, Fukuoka University
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MORIMOTO Shiro
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Morimoto S
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Iwamoto Takahiro
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Iwamoto Takahiro
Department Of Medical Engineering And Cardiology Institute Of Development Aging And Cancer Tohoku Un
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Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Morimoto Shiro
Department Of Pharmacology Osaka College Of Pharmacy
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Iwamoto T
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Takaoka M
Kyoto Univ. Kyoto
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IHARA Kimiko
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Ihara Kimiko
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Morimoto Shiro
Department of Chemical Engineering, Faculty of Engineering, Tokushima University
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