Cellular Ca2+ Dynamics in Urinary Bladder Smooth Muscle From Transgenic Mice Overexpressing Na+-Ca2+ Exchanger
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概要
- 論文の詳細を見る
The rise of Ca2+ concentration ([Ca2+]i) by reducing external Na+ in urinary bladder smooth muscle cells (UBSMCs) from transgenic mice overexpressing Na+/Ca2+ exchanger type-1.3 (NCX1.3tg/tg) was about 4 times as large as that in the wild-type (WT). NCX1 protein expression in UB increased about 4-fold in NCX1.3tg/tg. The Ca2+ release by caffeine in UBSMCs was comparable between NCX1.3tg/tg and WT, but [Ca2+]i decay was faster in NCX1.3tg/tg. Contractions induced by acetylcholine, 60 mM K+, or electrical stimulation were significantly smaller in UB segments of NCX1.3tg/tg. NCX worked in Ca2+-extrusion mode during these contractions in UBSMCs of both WT and NCX1.3tg/tg.
- 社団法人 日本薬理学会の論文
著者
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Kita Satomi
Department Of Pharmacology Faculty Of Medicine Fukuoka University
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Iwamoto Takahiro
Department Of Medical Engineering And Cardiology Institute Of Development Aging And Cancer Tohoku Un
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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MURATA Hidemichi
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Sawada Eiji
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura Hisao
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Hotta Shingo
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Murata Hidemichi
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Iwamoto Takahiro
Department of Pharmacology, School of Medicine, Fukuoka University, Japan
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Hotta Shingo
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Sawada Eiji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Yamamura Hisao
Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Kita Satomi
Department of Pharmacology, School of Medicine, Fukuoka University, Japan
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Murata Hidemichi
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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