Forefront of Na+/Ca2+ Exchanger Studies: Physiology and Molecular Biology of Monovalent Cation Sensitivities in Na+/Ca2+ Exchangers
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概要
- 論文の詳細を見る
Sensitivities of the reverse-mode Na+/Ca2+ exchange activity measured as the Na+i-dependent Ca2+ uptake to extracellular monovalent cations K+, Li+, and Na+ were compared between the K+-dependent (NCKX2) and the K+-independent Na+/Ca2+ exchanger (NCX1) overexpressed in a fibroblast cell. Interestingly, the exchange activity of NCKX2 was not influenced by Li+ while it was increased by K+. On the contrary, the activity of NCX1 was increased by Li+. Thus, the cation sensitivities to K+ and Li+ markedly differed between NCKX2 and NCX1. In addition, Na+ exerted a significantly smaller inhibitory effect on the activity in NCKX2 than in NCX1. The Na+/Ca2+ exchange activities of NCKX2 and NCX1 are considered to be regulated differentially via the respective binding site domains that have distinct sensitivities to the external monovalent cations.
- 公益社団法人 日本薬理学会の論文
著者
-
Nakamura Yuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Uehara Akira
Department Of Chemistry Faculty Of Science Kanazawa University
-
Iwamoto Takahiro
Department Of Medical Engineering And Cardiology Institute Of Development Aging And Cancer Tohoku Un
-
Imanaga Issei
Department Of Physiology Fukuoka University School Of Medicine
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